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17 Cards in this Set
- Front
- Back
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TdT+, CALLA +
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ALL
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neoplastic proliferation of virgin B cells (can't become plasma cells)
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CLL
often asymptomatic, smudge cells, warm hemolytic anemia, older adults |
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Mantle cell lymphoma; poor prognosis, CD5+, has what translocation?
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t(11;14)
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good prognosis in all hodgkin's lymphoma is associated with what two values?
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good prognosis = high lymphocytes, low reed-sternberg cells
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reed-sternberg cells are CD_ and _ +?
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Reed sternberg eclls are CD 15 and 30+ and are of B cell origin
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what is the most common Hodgkin's lymphoma?
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nodular sclerosing, excellent prognosis, collagen banding, lacunar cells, primarily young adults.
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basophilic stippling is associated with what 4 diseases?
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Basophilic stippling = ribosomal build up in RBC
Thalassemias Anemia of chronic disease Iron deficiency Lead poisoning (aka Sideroblastic anemia) |
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G6PD presents with which types of pathologic RBC cells?
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Heinz bodies (Hb that has been been oxidized from ferrous 2+ to ferric 3+ causing precipitation and damage to RBC membrane.
2. Bite cells |
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Target cell is associated with what 4 conditions?
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HbC disease
Asplenia Liver disease Thalassemia |
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what are the other names for prophobilinogen deaminase?
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uroporphorynogen I synthase
HMB synthase |
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what does HMB synthase do?
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converts porphobilinogen to HMB
- defected in acute intermittent porphyria |
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what does uroporphoryrinogen decarboxylase do?
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convert uroporphoryinogen III to copoporphoryinogen III
- defected in porphyria cutanea tarda |
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5 symptoms of AIP
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1. painful abdomen
2. red wine urine 3. polyneuropathy* 4. psych disturbances 5. precipitated by drugs (phenobarbital, griseofulvin, phenytoin)* |
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what are the highest to lowest #s in the WBC differential:
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Neutrophils (40-75%)
Lymphocytes Monocytes Eosinophils Basophils |
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3-5 lobe WBC- what are 5 different enzyme/granules inside?
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azurophilic granules (lysosomes)
hydrolytic enzymes lysozyme myeloperoxidase lactoferrin |
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protection against helminthic infections
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major basic protein - eosinophils
also produces histaminase and arylsulfatase (help limit reaction following mast cell degranulation) |
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Basophilic granules consist of what 3 things:
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1. heparin (anticoagulant)
2. histamine (vasodilator) 3. leukotrienes (LTD-4) |
