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10 Cards in this Set
- Front
- Back
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Is heme iron in hemoglobin and myoglobin in it's ferrous fe+2 or feric state Fe+3, can if be oxygenated or oxidized?
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heme iron is always in it's ferrous state Fe+2 reduced, it can be oxegenated but not oxidized
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what is the p50 of myoglobin?
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1 torr
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what is the p50 of hemoglobin?
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26 torr
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What does BPG bind to only and what does it do to oxygen affinity?
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Binds to T (tense-low affinity for oxygen- makes it harder for O2 to bind to tense form)
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T or R form of hemoglobin is is oxygenated form, more or less affinity?
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T=tense form- deoxygenated, low affinity for oxygen
R form= relaxed form high, oxygenated, high affinity for oxygen |
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The alpha globulin gene cluster is on what chromosome?
in adult life what genes are productive? |
chromosome 16
the two alpha genes |
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the beta globulin is on what chromosome?
in adult life what genes are productive |
chromosome 11
beta and delta genes |
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What is methemoglobin, and how is it formed?
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methemoglobin is the oxidized form of iron and it is completley useless in carrying oxygen, any dramatic increase in oxidizing factors can cause this to happen
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ferrochelatase does what?
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coproporphyrinogen III is transported back into the mitochondria this enzyme thows an iron on it
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Where does heme regulation act in the process of heme synthesis?
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acts on the first enzyme in the ALA dehydratase- in cytosol
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