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26 Cards in this Set
- Front
- Back
Hyperemia
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Local Inc in Vol of Bld
Active= local A. dilate Passive= COngestion |
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Acute Passive Congestion
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Shock, Sudden R-side Hrt Fail
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Chronic Passive Congestion
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L-Side Hrt Fail, Mitral Stenosis
Intra-Alveolar Hemosiderin Laden Macrophg= HrtFail Cells |
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Nutmeg Liver
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dilated/congested Cent V and srrnding brwn/yellow fatty liver cells
Bc R-side Hrt Fail (liver gets congested) |
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White Infarct
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Heart, Spleen, Kidney
|
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Red Infarct
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Lung, GI
Bc redundant bld supply Hemorrhage into infarct |
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Thrombosis
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V. Stasis, CHF, Polycythemia, Sickle Cell, Visceral Malig, OC
|
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Stabilize Platelet Plug
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Fibrinogen Bridges
and Fibrin |
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Limit Platelet Plug Form
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Prostacyclin (PGI2)
From Endothel Cells Antag TXA2 so limit further Platelet Agg |
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Extrinsic Coag Path
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Init by Tissue Factor
Eval by PT Meas Factor 2, 5, 7, 10, and fibrinogen |
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Intrinsic Coag Path
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Involve all Clot Factors (except 7,13)
Contact Activation: Factor12 (Hageman), PreK, HMWK, Factor11 Eval by PTT Meas 2,5,8,9,10,11,12,Fibrinogen |
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Fibrinolysis
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Pro-Enz Plasminogen to Plasmin (most imp fibrinolytic protease)
Splits Fibrin |
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Factor 5 Leiden
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Most commn Hered Thrombophila
Abnrm Factor5 w/alt cleavage site for ActProtC "Hereditary Resistnce to APC" |
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PT 20210A Transition
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(Thrombophilia)
G to A Mut in 3'UTR of PT Elev PT levels |
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Methylene THF Reductase Mut
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(Thrombophilia)
Inc serum Homocysteine A&V Thrombosis, Inc risk NT defect supplemnt Folic Acid |
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Antiphospholipid Ab Synd
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Prothrombotic D/O
V&A thromboemboli, Fetal loss, Thrombocytopenia Incidental bc Elev PTT (paradoxical) Some SLE (Lupus Anticoag) |
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Heparin Induced Thrombocytopenia
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Ab to Hep-Platelet Cmplx
|
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Arterial Thrombi
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Lines of Zahn
(Drk platelet/Light fibrin) |
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Venous Thrombi
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Drk Red
Bc grtr conc RBCs |
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Paradoxical Emboli
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L-Side Emboli that arise in V. Circ
Access to A by RtoL Shunt |
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Fat Emboli
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Chunks of Bone Marrow
Bc Severe/Mult Fractures Fat Emboli Synd= Pulmo distress, Cut Petechia, Neuro manifest |
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Edema
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Inc Hydrostatic Press (CHF)
Inc Cap Perm (inflam/burn) Inc Na Retention (renal/CHF) (Dec CO=Dec RBF=Act RAAS) |
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Anascara
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Generalized Edema
|
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Transudate
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Non-Inflam
Bc Alt Intravasc Hydrostatic/Osmotic Press Low Prot/SpecGrav<1.012 |
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Exudate
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Bc Inflam Inc Vasc Perm
High Prot/SpecGrav>1.02 But GLu low Bc leukos consume |
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Shock Stages
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Nonprogressive (Early):
Compensatory Mech maint perfus Progressive: Tiss Hypoperfus, Metab Acidosis Compens no longer adeq Irreversible: survival not possible |