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12 Cards in this Set
- Front
- Back
Reactive Conditions Causing Lymphadenopathy
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Infectious causes, Drug Reactions, Connective Tissue Disorders
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Features of Reactive Lymphadenitis
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1 Partially distort lymph node architecture 2 Often limited to certain lymph node groups 3 May have a distinctive histologic pattern
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Cat Scratch Disease causitive organism
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Bartonella henselae
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Toxoplasmosisn
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Classic Triad 1 Follicular hyperplasia 2 Epithelioid histiocytes impinging on germinal centers 3 Monocytoid B cell hyperplasia (i) B cells in the sinuses with a lot of cytoplasm (ii) “fried egg” appearance
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Infectious Mononucleosis pathological appearance
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1 Expansion of the paracortex (T cell zone) 2 “moth-eaten” appearance 3 Scattered large immunoblasts among small T cells 4 Reactive atypical lymphocytes in the peripheral blood
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Cat Scratch Disease microscopic appearancen
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1 Follicular hyperplasia 2 Stellate microabscesses 3 Necrotizing granulomas with lots of neutrophils
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Solid Tumors vs HP Neoplasms
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Solid Tumors: Carcinomas and sarcomas.Characterized by: 1Localized growth 2 Invasion 3 Metastasis HP Neoplasms: Leukemias and lymphomas. Characterized by: 1 Systemic disease 2 Replacement of normal marrow or lymph node elements 3Circulating tumor cells in the peripheral blood
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Acute vs. Chronic Leukemias
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Chronic Composed of more
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Lymphoma Classification (Hodgkin vs Non H)
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Hodgkin Lymphoma 1 Less common, 2 Pleomorphic growth pattern 3 Neoplastic cell is rare Non-Hodgkin Lyphomas 1 More commmon 2 Usually have a monomorphic growth pattern, 3 neoplastic cell = predominant cell
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Follicular Lymphoma
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1 Peripheral B cell lymphoma; 2 Morphology & immunophenotype reminiscent of germinal center B cells; (i) Nodular follicular architecture; (iii) Small cleaved lymphocytes
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Transformation
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A change in histologic appearance and clinical behavior from an indolent process to a more aggressive neoplasm
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Diagnosing Hematolymphoid Disordersn
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Step 1: History & Physical Step 2: Draw blood, Laboratory testing guided by H&P Step 3: get tissue; Peripheral blood, bone marrow, lymph node Step 4:Morphology, Immunophenotype, Cytogenetic and Molecular Analysis
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