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13 Cards in this Set
- Front
- Back
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Development of the myeloblasts
neutrophils, eosinophils, basophils |
Promyelocyte --> Myelocyte --> Metamyelocyte --> Stab cell (band) --> Mature cell type
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Diseases with basophilic stippling
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Thalassemias, anemia of chronic disease, iron deficiency anemia, lead poisoning
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Causes of eosinophilia
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Neoplasm
Asthma Allergy Collagen vascular Parasites |
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What's in azurophilic granules?
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Lysozyme, myeloperoxidase, lactoferrin
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Steps in primary hemostasis (platelets)
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1. Adhesion: Ia/Ib binds to basement membrane, vWF facilitates.
2. Activation (Gq mediated) increases IIb/IIIa surface expression and change in conformation. 3. Aggregation, occurs via IIb/IIIa interacting with fibrinogen |
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Which factors in the coag. cascade are glycoproteins
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V and VIII
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Extrinsic pathway:
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TF + VII --> VIIa
VIIa activates X --> Xa Xa converts prothrombin --> thrombin (IIa) Thrombin converts Fibrinogen--> fibrin (Ia) XIIIa does crosslinking to strengthen the clot |
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Intrinsic pathway
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12-->12a
11-->11a 9-->9a X-->Xa w/ factor VIII |
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What do protein C and S do?
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They inhibit VIIIa and Va
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Rh+ blood transfusion in an Rh- individual can do what?
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Cause massive IgG production the first time around.
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Causes of target cells
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HbC disease
Asplenia Liver disease Thalassemia |
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Where do you see burr cells?
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TTP/HUS
Also see helmet cells, schistocytes, poikilocytes. |
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in hemolysis, what happens to haptoglobin and LDH
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haptoglobin decreases LDH increases
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