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50 Cards in this Set

  • Front
  • Back
hemolytic anemia:
which bilirubin increased?
clinical signs?
unconjugated
jaundice and yellow sclarea
cold agglutins precipitated by what?
mycoplasma
IgM mediated
cold icream...mmm
what typically causes warm agglutins?
SLE, lymphoma, drugs
IgG mediated. warm weather is ggggreat
Erythrocytosis (increased RBCs) can be seen with what cancer?
renal cell carcinoma due to paraneoplastic syndrome with increased erythropoetin
CML:
genes involved?
t9:22. bcr-abl
immune mediated destruction of platelets ?
idiopathic thrombocytopenic purpura – destruction of platelets by the spleen. Will have increased megakaryocytes
CD16+ lymphocytes?
NK cells, which are not inducible and therefore would not be increased in number regardless of infection
lacunar cells suggest what?
nodular sclerosing variant of hodgkins disease.
treatment of lead poisoning?
Edentate calcium disodium (EDTA) is used parentally for the chelation of lead
chronic congestive splenomegaly is associated with what condition?
hepatic cirrhosis
distinctive histologic finding in hodgkins lymphoma?
reid-sternberg cell - owl eye nucleus
R-S cells can be found surrounded by mature lymphocytes, eosinophils, and neutrophils
reactive hyperplasia of the spleen seen with what conditions?
Chronic inflammatory disorders (e.g. RA)
sickle cell genetic mechanism?
point mutation leading to substitution of valine for glutamate at the 6th position of the beta globin chain
which form of leukemia, is characterized by pancytopenia rather than increased numbers of circulating cells
hairy cell leukemia
positive for tartrate-resistant acid phosphatase (TRAP)
characteristic cells (which are not always hairy) of hairy cell leukemia
haptoglobin:
function?
increases or decreases in hemolysis?
serum protein that binds free Hg in serum, forming a tight complex
decreases in hemolysis
organism associated with cat scratch disease?
baronella hensalae
the most common adult non-hodgkins lymphoma?
-Follicular lymphoma (small cleaved B cell)
t(14:18)
bcl-2 expression
Follicular lymphoma (small cleaved B cell)
hematologic lab abnormalities seen in DIC
prolonged PT and PTT, decreased platelets.
schistocytes (fragmented RBCs) are seen on peripheral blood smear. Often due to obstetric complications
thoracic duct drains the whole body except what area?
right arm, the right side of the chest, and the right side of the head - drain into R lymphatic duct
what important clinical finding is associated with B12 deficiency but not folate deficiency?
neurologic problems
t(15;17)
seen in acute promyelocytic leukemia (M3) – proliferation of promyelocytes
Stage IIIb hodgkins disease?
III - – involvement of lymph nodes on both sides of diaphragm.
B - constitutional symptoms present
M3 leukemia?
acute promyelocytic leukemia with auer rods
PT and PTT in TTP?
normal
TTP - decreased platelets, hemolytic anemia with neurologic symptoms
how can you differentiate DIC from TTP?
coag tests. In both hemolysis is present, but the PT and PTT are prolonged only in DIC.
how is HUS different from TTP
mental status changes are not part of the clinical picture of HUS, but are in TTP
nosebleeds indicate platelet or coag disorder?
platelet
Hemarthroses (bleeding into joints), easy bruisibility suggests what kind of disorder
coagulation disorder, e.g. hemophilia
thoracic duct drains the whole body except what area?
right arm, the right side of the chest, and the right side of the head - drain into R lymphatic duct
what important clinical finding is associated with B12 deficiency but not folate deficiency?
neurologic problems
t(15;17)
seen in acute promyelocytic leukemia (M3) – proliferation of promyelocytes
Stage IIIb hodgkins disease?
III - – involvement of lymph nodes on both sides of diaphragm.
B - constitutional symptoms present
M3 leukemia?
acute promyelocytic leukemia with auer rods
PT and PTT in TTP?
normal
TTP - decreased platelets, hemolytic anemia with neurologic symptoms
how can you differentiate DIC from TTP?
coag tests. In both hemolysis is present, but the PT and PTT are prolonged only in DIC.
how is HUS different from TTP
mental status changes are not part of the clinical picture of HUS, but are in TTP
nosebleeds indicate platelet or coag disorder?
platelet
Hemarthroses (bleeding into joints), easy bruisibility suggests what kind of disorder
coagulation disorder, e.g. hemophilia
thoracic duct drains the whole body except what area?
right arm, the right side of the chest, and the right side of the head - drain into R lymphatic duct
what important clinical finding is associated with B12 deficiency but not folate deficiency?
neurologic problems
t(15;17)
seen in acute promyelocytic leukemia (M3) – proliferation of promyelocytes
Stage IIIb hodgkins disease?
III - – involvement of lymph nodes on both sides of diaphragm.
B - constitutional symptoms present
M3 leukemia?
acute promyelocytic leukemia with auer rods
PT and PTT in TTP?
normal
TTP - decreased platelets, hemolytic anemia with neurologic symptoms
how can you differentiate DIC from TTP?
coag tests. In both hemolysis is present, but the PT and PTT are prolonged only in DIC.
how is HUS different from TTP
mental status changes are not part of the clinical picture of HUS, but are in TTP
nosebleeds indicate platelet or coag disorder?
platelet
Hemarthroses (bleeding into joints), easy bruisibility suggests what kind of disorder
coagulation disorder, e.g. hemophilia