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44 Cards in this Set
- Front
- Back
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6MP
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Blocks de novo purine synthesis. Activated by HGPRTase.
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Cytarabine
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Inhibits DNA polymerase.
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Cyclophosphamide, ifosfamide
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Alkylating agents; covalently x-link (interstrand) DNA at guanine N-7. Require bioactivation by liver.
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Nitrosureas
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Alkylate DNA. Require bioactivation. Cross bld-brain barrier-->CNS
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Cisplatin, carboplatin
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Act like alkylating agents
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Busulfan
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Alkylates DNA
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Doxorubicin (Adriamycin), daunorubicin
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Generate free readicals and noncovalently interacalate in DNA (creating breaks in DNA strand to decrease replication).
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Dactinomycin
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Intercalates in DNA.
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Bleomycin
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Induces formation of free radicals, which cause breaks in DNA strands.
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Etoposide (VP-16)
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G2-phase-specific agent that inhibits topoisomerase II and increases DNA degradation.
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Prednisone
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May trigger apoptosis. May even work on nondividing cells.
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Tamoxifen, raloxifene
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Receptor antagonists in breast, agonists in bone; block the binding of estrogen
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Trastuzumab (Herceptin)
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Monoclonal Ab against HER-2 (erb-B2)
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Imatinib (Gleevac)
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Philadelphia chromosome brc-abl tyrosine kinase inhibitor.
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Vincristine, vinblastine
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Acts on microtubules to inhibit spindle formation during mitosis.
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Paclitaxel, other taxols
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Inhibits microtuble disassembly.
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Leukemias, lymphomas (not CLL or Hodgkins)
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6MP
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AML
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Cytabarine
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Non-hodgkins lymphoma, breast and ovarian carcinomas. Also immunosuppressants.
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Cyclophosphamide, ifosfamide
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Brain tumors (including glioblastoma multiforme)
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Nitrosoureas
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Testicular, bladder, ovary, and lung carcinomas.
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Cisplatin, carboplatin
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CML
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Busulfan
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Part of the ABVD combination regimen for Hodgkin's and for myelomas, sarcomas, and solid tumors (breast, ovary, lung).
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Doxorubicin (Adriamycin), Daunorubicin
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Wilms tumor, Ewings sarcoma, rhabdomyosarcoma
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Actinomycin D
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Testicular cancer, lymphomas (part of the ABVD regimen for Hodgkins)
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Bleomycin
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Small cell carcinoma of the lung and prostate, testicular carcinoma.
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Etoposide
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Most commonly used glucocorticoid in cancer chemotherapy. Used in CLL, Hodgkin's lymphomas (part of the MOPP regimen). Also an immunosuppressant used in autoimmune diseases.
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Prednisone
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Breast cancer. Also used to prevent osteoporosis.
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Tamoxifen
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Metastatic breast cancer.
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Trastuzumab (Herceptin)
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CML, GI stromal tumors
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Imatinib (Gleevac)
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Part of the MOPP regimen for lymphoma, Wilm's tumor, choriocarcinoma
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Vincristine, Vinblastine
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Ovarian and breast carcinomas.
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Paclitaxel, other taxols
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Myelosuppression; hemorrhagic cystitis, which an be partially prevented with mesna.
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Cyclophosphamide, ifosfamide
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CNS toxicity
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Nitrosoureas
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Nephrotoxicity, acoustic nerve damage
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Cisplatin, carboplatin
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Pulmonary fibrosis, hyperpigmentation
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Busulfan
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Cardiotoxicity; also myelsuppression and marked alopecia. Toxic extravasation.l
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Doxorubicin (Adriamycin), daunorubicin
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Pulmonary fibrosis, skin changes, but min myelosuppression.
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Bleomycin.
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May increase the risk of endometrial carcinoma via partial agonist effects; "hot flashes."
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Tamoxifen
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Does not cause endometrial carcinoma because it is an endometiral antagonist.
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Raloxifene
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Cardiotoxicity
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Trastuzumab
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Fluid retention.
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Imatinib
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Neurotoxicity (areflexia, peripheral neuritis, paralytic ileus.
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Vincristine
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BLASTs bone marrow.
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VinBLASTine
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