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53 Cards in this Set
- Front
- Back
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neoplasms associated with Down syndrome?
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ALL, AML
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neoplasms associated with tuberous sclerosis?
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astrocytoma and cardiac rhabdomyoma
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neoplasm associated with Plummer-Vinson syndrome (atrophic glossitis, esophageal webs, anemia; all due to iron deficiency)
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squamous cell carcinoma of the esophagus
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neoplasms associated with Paget's disease fo bone
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secondary osteosarcoma and fibrosarcoma
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neoplasm associated with immunodeficiency states
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malignant lymphoma
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neoplasms associated with AIDS
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aggressive malignant lymphomas (non-Hodgkin's) & Kaposi's sarcoma
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neoplasms associated with acanthosis nigricans
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visceral malignancy (stomach, lung, breast, uterus)
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abl
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CML (oncogene)
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c-myc
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Burkitt's lymphoma (oncogene)
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bcl-2
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follicular and undifferentiated lymphomas (inhibits apoptosis) (oncogene)
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erb-B2
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breast, ovarian, and gastric carcinomas (oncogene)
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ras
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colon carcinoma (oncogene)
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L-myc
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Lung tumor (oncogene)
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N-myc
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neuroblastoma (oncogene)
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ret
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MEN II & III (oncogene)
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Rb
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13q; retinoblastoma, osteosarcoma (tumor suppressor)
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BRCA1 and 2
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17q, 13q; breast and ovarian cancer (tumor suppressor)
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p53
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17p; most human cancers, Li-Fraumeni syndrome (tumor suppressor)
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p16
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9p; melanoma (tumor suppressor)
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APC
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5q; colorectal cancer (tumor suppressor)
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WT1
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11q; Wilms' tumor (tumor suppressor)
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NF1
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17q; Neurofibromatosis type I (tumor suppressor)
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NF2
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22q; Neurofibromatosis type II (tumor suppressor)
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DPC
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18q; pancreatic cancer (tumor suppressor)
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DCC
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18q; colon cancer (tumor suppressor)
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PSA
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prostatic carcinoma
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CEA
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carcinoembryonic antigen; very nonspecific but produced by about 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas
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alpha-fetoprotein
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hepatocellular carcinomas; nonseminomatous germ cell tumors of the testes (e.g. yolk sac tumor)
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beta-HCG
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Hyatidiform mole, Choriocarcinomas, and Gestational trophoblastic tumors
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CA-125
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ovarian, malignant epithelial tumors
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S-100
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melanoma, neural tumors, astrocytomas
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alkaline phosphatase
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metastases to bone, obstructive biliary disease, Paget's disease of bone
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bombesin
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neuroblastoma, lung and gastric cancer
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TRAP
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tartrate-resistant acid phosphatase; hairy cell leukemia, a B cell neoplasm
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HTLV-1
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adult T cell leukemia
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HBV, HCV
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hepatocellular carcinoma
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EBV
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Burkitt's lymphoma, nasopharyngeal carcinoma
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HPV
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cervical carcinoma (16, 18), penile/anal carcinoma
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HHV-8
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Kaposi's sarcoma, body cavity fluid B cell lymphoma
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aflatoxins
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liver (hepatocellular carcinoma)
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vinyl chloride
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liver (angiosarcoma)
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CCL4
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liver (centrilobular necrosis, fatty change)
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nitrosamines
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esophagus, stomach
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asbestos
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lung (mesothelioma and bronchogenic carcinoma)
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arsenic
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skin (squamous cell carcinoma)
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naphthalene (analine) dyes
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bladder (transitional cell carcinoma)
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alkylating agents
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blood (leukemia)
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t(9;22)
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CML (bcr-abl hybrid)
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t(8;14)
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Burkitt's lymphoma (c-myc activation)
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t(14;18)
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follicular lymphomas (bcl-2 activation)
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t(15;17)
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M3 type of AML - responsive to all-trans retinoic acid
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t(11;22)
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Ewing's sarcoma
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t(11;14)
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mantle cell lymphoma
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