Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
42 Cards in this Set
- Front
- Back
|
heparin
|
bleeding
thrombocytopenia (HIT) osteoporosis DDIs |
|
|
Warfarin
|
bleeding
teratogenic skin/tissue necrosis DDI |
|
|
Aspirin
|
gastric ulcer
bleeding hyperventilation Reye's syndrome tinnitus (CNVIII) Respiratory alkalosis metabolic acidosis |
|
|
ticlopidine
|
neutopenia
|
|
|
abciximab
|
bleeding
thrombocytopenia |
|
|
5-fluorouracil
|
myelosuppression NOT reversible with leucovorin
photosensitivity (can rescue with thymidine |
|
|
6-mercaptopurine
|
bone marrow
Gi Liver increased toxicity with allopurinol since its metabolized by xanthine oxidase |
|
|
cytarabine (ara-C)
|
leukopenia
thrombocytopenia megaloblastic anemia |
|
|
cyclophosphamide
|
myelosuppression
hemorrhagic cystitis (partially prevented with mesna) |
|
|
ifosfamide
|
myelosuppression
hemorrhagic cystitis (partially prevented with mesna) |
|
|
nitrosoureas
|
CNS toxicity (dizziness, ataxia)
|
|
|
cisplatin
|
nephrotoxicity
acoustic nerve damage |
|
|
carboplatin
|
nephrotoxicity
acoustic nerve damage |
|
|
busulfn
|
pulmonary fibrosis
hyperpigmentation |
|
|
doxorubicin (adriamycin)
|
cardiotoxicity
myelosuppression marked alopecia toxic extravasation |
|
|
daunorubicin
|
cardiotoxicity
myelosuppression marked alopecia toxic extravasation |
|
|
dactinomycin (actinomycin D)
|
myelosuppression
|
|
|
bleomycin
|
pulmonary fibrosis
skin changes minimal myelosuppression |
|
|
hydroxyurea
|
bone marrow suppression
GI upset |
|
|
etoposide (VP-16)
|
myelosuppression
GI irritation alopecia |
|
|
alopecia
|
doxorubicin
daunorubicin etoposide |
|
|
myelosuppression
|
methotrexate
5-fluoro (not reversible) cyclophosphamide ifosfamide doxorubicin daunorubicin dactinomycin etoposide paclitxel and other taxols |
|
|
photosensitivity
|
5-fluoro
|
|
|
GI
|
6-mercaptopurine
hydroxyurea etoposide |
|
|
megaloblastic anemia
|
cytarabine (ara-C)
|
|
|
CNS toxicity
|
nitrosoureas (dizziness, ataxia)
platins (nephropathy, acoustic nerve damage) vincristine, vinblastine (areflexia, peripheral neuritis |
|
|
thrombocytopenia
|
cytarabine (ara-C)
ticlopidine abciximab thrombocytopenia (HIT) |
|
|
pulmonary fibrosis
|
busulfan
|
|
|
hyperpigmentation
|
busulfan
|
|
|
cardiotoxicity
|
doxorubicin (adriamycin)
daunorubicin trastuzumab (herceptin) |
|
|
bleeding
|
abciximab
heparin warfarin thrombolytics (streptokinase, urokinase, tPA, APSAC) |
|
|
teratogens
|
warfarin
|
|
|
osteoporosis
|
heparin
prednisone |
|
|
fatty change in liver
|
methotrexate
|
|
|
methotrexate
|
myelosuppression (reversible with leucovorin rescue)
mucositis macrovesicular fatty change in liver |
|
|
mucositis
|
methotrexate
|
|
|
skin necrosis
|
warfarin
|
|
|
photosensitivity
|
5-fluoro
|
|
|
allopurinol toxicity
|
6-mercaptopurine
|
|
|
hemorrhagic cystitis
|
cyclophosphamide
ifosfamide (prevented partly by mesna) |
|
|
hyperpigmentation
|
busulfan
|
|
|
bone marrow suppression
|
Vinblastine
hydroxyurea |
