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48 Cards in this Set
- Front
- Back
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erythrocyte
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gas exchange, biconcave; source of energy - glucose
survival time- 120 days |
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anisocytosis
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varying sizes
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poikilocytosis
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varying shapes
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reticulocyte
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immature erythrocyte
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basophil
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mediates allergic reaction
densely basophilic granules containing heparin (anticoag), histamine (vasodilator), and other vasoactive anmines, and LTD4 |
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basophilic stippling
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thalasemias
anemia of chronic disease iron def anemia lead poisoning |
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mast cell
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mediates allergic reaction
degran: histamine, heparin, eosinophilic chemotactic factors can bind IgE to membrane type I HS reactions |
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Cromolyn sodium
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prevents mast cell degranulation
tx asthma |
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eosinophils
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bilobed nucleus
defense against helminithic and protozoan infections (major basic protein) highly phagocytic for antigen-antibody complexes |
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eosinophilia causes
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neoplasm, asthma, allergic processes, collagen vascular disease, parasites, Churg-Strauss, AIN, Addisons, drugs
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Neutrophil
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acute inflammatory response
bilobed nucleus; granules contain hydrolytic enzymes, lysozyme, MPO, lactoferrin |
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hypersegmented polys
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seen in vit B12/folate def
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monocyte
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frosted glass cytoplasm, differentiates into macrophages in tissues
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macrophage
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phagocytosis bacteria, cell debris, senescent RC, scavenges damaged cells and tissues
activated by gamma IFN |
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B lympho
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humoral response; produce antibodies
matures in marrow, migrates to peripheral tissues (LN follicles, white pulp of spleen, unencap lymphoid tissue) difft into plasma cell; has memory (VAX) |
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B cell surface markers
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CD 19, 20, 21, IgD, IgM
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Plasma cell
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abundant RER, well devloped golgi
produce antibody to a specific antigen |
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plasma cell neoplasm
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multiple myeloma
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russell bodies
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accumulation of Ig in plasma cells in multiple myeloma
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T lymph0
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mediates cellular immune response; originate from stem cells in the bone marrow but matures in the thymus
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cytotoxic T
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MHC 1
CD 8 |
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helper T
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MHC II
CD 4 |
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dendritic cells
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professional APCs; express MHC II and FcR on surface
main inducers of primary AB response |
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intrinsic pathway
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collagen, BM, activated platelets-->XII, XI, IX, X (meets extrinsic), thrombin, fibrin, clot
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factor VIII
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makes IXa to X
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def of VIII
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hemophilia A
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def of IX
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hemophilia B
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extrinsic
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tissue factor VII,X, thrombin, fibrin, clot
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protein C and S
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inactivate Va and VIIIa, vit K dependent
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Antithrombin III
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inactivates thrombin, IXa, Xa, and XIa
inactivated by heparin |
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vW factor
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platelet aggregation to exposed collagen
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platelet produces Ca for
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XIa to IX
IXa to X VII to VIIa Xa to prothrombin (via Va) |
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citrate and Ca
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citrate binds to Ca decreasing clotting
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tpa
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generates plasmin, which cleaves fibrin
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factor V leiden mutation
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resistance to activated protein C
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bradykinin
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increases vasodilation, increases permeability, increases pain
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A blood group
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A antigen on RBC surface, B antibody in plasma
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B blood group
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B antigen on RBC surface, A antibody in plasma
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AB
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universal recipient
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O
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neither A nor B antigen; both antibodies in plasma- universal donor
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Rh+
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transfusion into Rh- person can result in massive IgG production
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macroovalocyte
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megaloblastic anemia (also see hypersegemented PMNs), marrow failure
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helmet cell, schistocyte
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DIC, traumatic hemolysis
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teardrop ccell
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myeloid metaplasia with myelofibrosis
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Target cell
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Thalassemia, HbC disease, asplenia, liver disease
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Poikilocytes
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nonuniform shapes in TTP/HUS, microvascular damage, DIC
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Burr cell
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TTP/HUS
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psammoma bodies
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papillary adenocarc of thyroid
serous papillary cystadenoma of ovary meningioma malignant mesothelioma (laminated concentric calc spherules) |
