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24 Cards in this Set
- Front
- Back
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prognostic marker for CLL
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ZAP 70
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ZAP 70
positive good or bad prognosis? |
positive ZAP70 is bad prognosis in CLL
call it positive if >20%, but usually all or nothing. |
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what is ZAP 70
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surrogate marker for mutation in CLL heavy chain post germinal ctr
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what cells do you lok for ZAP70 staining on and what interferes?
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in PB of CLL, mostly B cells anyway, so okay
in BM, T, B, and grans, (T and grans normally positive, so do CD3 etc and "subtract out" T to see expression on B cells.) |
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CD19+CD5+ loma?
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CLL or Mantle cell
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CD19+ CD5- CD10+ loma
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Follicular
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CD19+ CD5+ CD23+ Loma
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CLL
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CD19+CD5+FMC7+ loma
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Mantle cell
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cyclin D1+ loma
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Mantle cell
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CD19+ CD5- CD11c+ FMC7+
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Hairy cell
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CD19+ CD11c+ CD103+ TRAP+
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Hairy cell
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smudge cells in PB
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CLL
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how to prevent smudge cells in PB
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add albumin to PB before smear
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proliferation centers
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CLL
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prolymphs in PB
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CLL
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paraimmunoblasts in LN
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CLL
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small lymphs with clumped/cracked/mosaic chromatin
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CLL
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prolymphs and paraimmunoblasts have nucleoli T or F
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True prolymphs and paraimmunoblasts have nucleoli
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t(11;14)
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Mantle cell IgH and cyclin D1
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CD19+ CD5+ loma with pale hyalinized vessels
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Mantle cell
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CD19+CD5+ loma with only small cells resembling centrocytes
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Mantle cell
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highest genetic predisposition of all heme malignancies
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CLL (5-10% familial)
2-7 x incr risk in first degree relative |
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best way to detect t(11;14)
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best way is by FISH (~100%)
karyotype only detects 65% |
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immunophenotype of normal germinal center B cells
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CD20+
CD10+ bcl6+ bcl2 neg |
