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16 Cards in this Set
- Front
- Back
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Auer rods & granules indicated what?
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AML (Acute Myeloid Leukemia) or myelodysplasia
Auer rods are typical of blast cells |
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Smudge cells are indicitive of _____?
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CLL
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Name the myeloproliferative diseases
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P. Vera
ET (essential thrombocythemia) CML (chronic myelogenous leukemia Chronic Idiopathic myelofibrosis |
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Philadelphia Chromosome
(what is it) |
t(9:22)
fusion of BCR/ABL genes, which results in enhanced Tyrosine Kinase activity |
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Philadelphia Chromosome
(what's it indicitive of) |
All CML: with 210-kDa protein
Some ALL: 190 or 210 kDa Chronic Neutropilic Leukemia: 230-kDa protein & lower WBC & Slower progression |
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diagnosis of CML
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hx & pe
blood smear & bm biopsy (WBCs of various diff, blasts < 5%) cytogenetics (Phila chrom); PCR (looking for BCR-ABL gene) LAP (low) |
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Hydroxyurea does what?
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decreases marrow proliferation; causes a hematologic response, but remission is rare
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Tyrosine Kinase is responsible for what?
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Stimulates the growth cycle (mitosis, etc...).
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Tx of CML
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Hydroxyurea
Interferon ST1571 (Gleevec, Imatinib) |
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Interferon does what?
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is anti-proliferative; it restores cell adhesion to marrow stroma, and decreases Philadelphia chromez by 35%!
Complete hematologic response (30~68%)! |
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How does ST1571 work (Gleevec, Imatinib)?
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Inhibits tyrosine kinase, decreasing mitosis signals & promoting apoptosis
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CD5+ CD19+ CD23+
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CLL
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CD5+ CD19+ CD23-
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Mantle Cell lymphoma
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CLL Staging Criteria (0-IV)
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0: lymphocytosis in PB & BM
I: 0 + lymphadenopath II: + spleen & liver III: + anemia IV: thrombocytopenia |
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CD5- CD23- CD25+ CD103+
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Hairy Cell Leukemia
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Tx for Hairy Cell Leukemia
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2-CDA (7 days = 90% complete response)
... also in-alpha, pentostatin, or splenectomy |
