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16 Cards in this Set

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Auer rods & granules indicated what?
AML (Acute Myeloid Leukemia) or myelodysplasia
Auer rods are typical of blast cells
Smudge cells are indicitive of _____?
CLL
Name the myeloproliferative diseases
P. Vera
ET (essential thrombocythemia)
CML (chronic myelogenous leukemia
Chronic Idiopathic myelofibrosis
Philadelphia Chromosome
(what is it)
t(9:22)
fusion of BCR/ABL genes, which results in enhanced Tyrosine Kinase activity
Philadelphia Chromosome
(what's it indicitive of)
All CML: with 210-kDa protein
Some ALL: 190 or 210 kDa
Chronic Neutropilic Leukemia: 230-kDa protein & lower WBC & Slower progression
diagnosis of CML
hx & pe
blood smear & bm biopsy (WBCs of various diff, blasts < 5%)
cytogenetics (Phila chrom);
PCR (looking for BCR-ABL gene)
LAP (low)
Hydroxyurea does what?
decreases marrow proliferation; causes a hematologic response, but remission is rare
Tyrosine Kinase is responsible for what?
Stimulates the growth cycle (mitosis, etc...).
Tx of CML
Hydroxyurea
Interferon
ST1571 (Gleevec, Imatinib)
Interferon does what?
is anti-proliferative; it restores cell adhesion to marrow stroma, and decreases Philadelphia chromez by 35%!
Complete hematologic response (30~68%)!
How does ST1571 work (Gleevec, Imatinib)?
Inhibits tyrosine kinase, decreasing mitosis signals & promoting apoptosis
CD5+ CD19+ CD23+
CLL
CD5+ CD19+ CD23-
Mantle Cell lymphoma
CLL Staging Criteria (0-IV)
0: lymphocytosis in PB & BM
I: 0 + lymphadenopath
II: + spleen & liver
III: + anemia
IV: thrombocytopenia
CD5- CD23- CD25+ CD103+
Hairy Cell Leukemia
Tx for Hairy Cell Leukemia
2-CDA (7 days = 90% complete response)
... also in-alpha, pentostatin, or splenectomy