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29 Cards in this Set
- Front
- Back
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The concentration of various enzymes in the body fluids is a reflection of ____
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The concentration of various enzymes in the body fluids is a reflection of ____
over state of the organism. |
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Steady state levels of various enzymes in the blood are a result of ____?
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Steady state levels of various enzymes in the blood are a result of ____?
1. normal cellural activity 2. steady and constant release by various cells 3. constant removal from the circulation (liver and kidney) |
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When changes in the steady state occur?
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When changes in the steady state occur?
at cell death |
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At what situations the level of enzyme activity in the blood related to tissue damage?
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At what situations the level of enzyme activity in the blood related to tissue damage?
Acute |
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High levels of Aldolase B in blood tells u what?
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High levels of Aldolase B in blood tells u what?
muscle damage |
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High levels of pyruvate kinase in blood tells u what?
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High levels of pyruvate kinase in blood tells u what?
muscle damage |
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High levels of aspartate aminotransferase in blood tells u what?
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High levels of aspartate aminotransferase in blood tells u what?
liver damage |
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High levels of these enzymes markers for liver disease/injury:
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High levels of these enzymes markers for liver disease/injury:
1. hexokinase 2. alcohol dehydrogenase 3. aspartate aminotransferase 4. alanine aminotransferase 5. glutamate dehydrogenase |
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High levels of these enzymes markers for muscle disease/injury
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High levels of these enzymes markers for muscle disease/injury
1. pyruvate kinase 2. aldolase B 3. aspartate aminotransferase 4. alanine aminotransferase |
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High levels of these enzymes markers for RBC disease/injury
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High levels of these enzymes markers for RBC disease/injury
G-6-P dehydrogenase |
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specific activity, units of activity defined:
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specific activity, units of activity defined:
amt. of substrate converted to product per unit time 1U=1 micromol/min |
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LDH isoenzyme and it's 4 subunits:
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LDH isoenzyme and it's subunits:
I1- HHHH heart only I2- HHHM mainly heart I3- HHMM heart and muscle I4- HMMM mainly muscle I5- MMMM muscle only |
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Acute Hepatitis enzyme markers:
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Acute Hepatitis enzyme markers:
1. AspAT increases 10-150x 2. AlaAT increases 20-200x 3. Alkaline P increases (due to biliary onstruction) dark color stool 4. decreased cholinesterase |
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Subchronic Hepatitis:
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Subchronic Hepatitis:
AspAt not return to normal, stays elevated |
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Chronic hepatitis and cirrhosis
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Chronic hepatitis and cirrhosis:
1. AspAT increases 2-8x 2. AlaAT increases 2-8x 3. GDH increases |
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Hepatic coma
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Hepatic coma
1. Asp AT decreases 2. LDH, MDH, aldolase increases |
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Cirrhosis w ascites
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Cirrhosis w ascites
Early: 1. AspAT increases 2. AlaAT increases |
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Other causes of liver disease
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Other causes of liver disease
adipohepatic acute poisoning alcohol intoxication |
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Cardiac infarction:
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Cardiac infarction:
1. time dependance 2. size vs levels transaminase increases 10x creatine kinase increases 3-6x Highest 1-2days: CPK 4-5 days Asp AT 4-6 days Aldolase B 8-10 days LDH for longest time also |
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Duchenne;s muscular dystrophy enzyme markers
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Duchenne;s muscular dystrophy enzyme markers
Asp AT increases CK increases Aldolase B increases |
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Heavy muscular work causes enzyme increase in:
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Heavy muscular work causes enzyme increase in:
CK- mild exertion Alkaline and acid P and amylase no change |
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Serum enzyme for
MI and viral hep? |
Serum enzyme for
MI and viral hep? Aminostranferases Asp (SGOT) and Al (SGPT) |
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Serum enzyme for
acute pancreatitis? |
Serum enzyme for
acute pancreatitis? Amylase and Lipase |
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Serum enzyme for
hepatolenticular degenration (wilson disease)? |
Serum enzyme for
hepatolenticular degenration (wilson disease)? Ceruloplasmin |
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Serum enzyme for
muscle disorder and MI? |
Serum enzyme for
muscle disorder and MI? Creatine Phosphokinase |
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Serum enzyme for
Various liver diseases |
Serum enzyme for
Various liver diseases gamma glutamyl transpeptidase |
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Serum enzyme marker for Mi?
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Serum enzyme marker for Mi?
LDH |
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Serum enzyme marker for metastatic carcinoma of prostate?
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Serum enzyme marker for metastatic carcinoma of prostate?
phosphatase, acid |
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Serum enzyme marker for various bone disorders, obstructive liver disease?
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Serum enzyme marker for various bone disorders, obstructive liver disease?
phosphatase, alkaline |
