Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
13 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
vWD
|
PTT prolongation
Bleeding time prolongation Ristocetin cofactor decreased |
DESMOPRESSIN
vWF concentrate Factor VIII concentrate |
|
|
K deficiency
|
Prolonged antibiotic use
PT prolongation (2, 7, 10 = extrinsic) |
K-injections (ppx in liver failure)
FFP |
|
|
Hemophilia A
(VIII deficiency) |
PTT prolongation (VIII, IX = intrinsic)
PT normal Hemearthrosis |
Desmopressin (increase vWD)
Transfusions Factor VIII concentrate |
|
|
Hemophilia B
(IX deficiency) |
PTT prolongation (VIII, IX = intrinsic)
PT normal Hemearthrosis Desmopressin INEFFECTIVE |
Transfusions
Factor IX concentrate |
|
|
DIC
|
Jaundice, cyanosis (thrombotic)
Shock PT, PTT, bleeding time prolonged Fibrinogen low (clot precursor depletion) Fibrin split product, D-dimer high |
Platelets
FFP Cryoprecipitate Heparin (chronic thrombi) |
|
|
Nutritional thrombocytopenia
|
EtOH
B12 deficiency Folate deficiency Aplastic anemia |
|
|
|
Splenic sequestration
|
Splenomegaly
Marrow biopsy normal |
|
|
|
HIT
|
Antiplatelet antibodies
Diffuse thrombosis > 50% decrease in platelet level |
Stop heparin
Direct thrombin inh. (LEPIRUDIN, ARGATROBAN) |
|
|
ITP
|
Autoimmune (antiplatelet antibodies)
Platelets < 50,000 |
Self-limited (kids)
Steroids, IVIG, plasmapheresis, splenectomy (adults) |
|
|
HUS-TTP
|
EHEC/Shigella infection
Autoantibody causes platelet aggregation ARF, uremia Hemolysis Fever |
Steroids
Plasmapheresis FFP |
|
|
Antiphospholipid syndrome
|
Arterial + venous thromboses in pregnancy
PTT prolongation (artifact) |
Heparin (pregnancy)
Hydroxychloroquine ASA (alternative) |
|
|
HELLP
|
Elevated LFT
Hemolytic anemia Eclampsia sequella Schistocytes on smear |
Deliver if > 34 weeks
BP control, steroids to fetus if preterm |
|
|
FVL
|
AD (incomplete dominance)
Protein C can't inactivate mutant factor V DVT PTT, PT, viper venom time shortened |
Anticoagulate DVT's, INR 2-3
(lifelong Rx if recurrent) |
