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36 Cards in this Set
- Front
- Back
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3 ways that cells break down proteins
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ca dep
ubiquitin lysosomal |
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HIV Rx that causes BM suppression
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zidovudine
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treatment for lead poisoning
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adults
-succimer -EDTA children -dimercaprol -EDTA -succimer |
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Dx: child with anemia since birth, cure with splenectomy
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hereditary spherocytosis
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complications of hereditary spherocytosis
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anemia/jaundice
pigment stones splenomegaly coombs negative |
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what is the coombs test
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RBC agglutination with the addition of antihuman antibody
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Ig seen in cold agglutinins
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IgM
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when do you see cold agglutinins
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mycoplasma
EBV malignancy |
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Ig seen in warm agglutinins
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IgG
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when do you see warm agglutinins
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virus
SLE malignancy congenital immune abnormality |
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what are schistocytes
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helmet cells
seen in -DIC -TTP |
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what protozoa can cause hemolytic anemia
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babesia
malaria |
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hematologic disorder a/w:
hams test |
PNH
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hematologic disorder a/w:
DEB test |
fanconis anemia
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hematologic disorder a/w:
heinz bodies |
G6PD
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hematologic disorder a/w:
basophilic stippling |
Thalassemia
AOCD Iron def lead poisoning |
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hematologic disorder a/w:
osmotic fragility |
spherocytosis
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Dx and Rx: 11 year old with chronic non healing ulcer on his foot, x ray shows calcified spleen
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sickle cell
hydroxyurea |
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what type of cells are associated with microangiopathic anemia
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schistocytes
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what is a/w microangiopathic anemia
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DIC
TTP SLE Malignant HTN |
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what can cause macroangiopathic anemia
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prosthetic valves
aortic stenosis |
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when would you usually see a coombs positive test
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autoimmune hemolysis
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how can you differentiate intravascular from extravascular hemolysis
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intra
-decreased haptoglobin -no splenomegaly extra -increased UCB -splenomegaly |
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Rx for spherocytosis
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splenectomy
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what virus can lead to aplastic crisis
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parvo B19
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what causes the damage in G6PD def
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failure of HMP shunt under oxidative stress
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what makes G6PD def worse
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sulfa drugs
infection fava beans |
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what cells are a/w G6PD def
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heinz bodies
bite cells |
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a/w hemolytic anemia in a new born
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pyruvate kinase def
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what causes the damage in pyruvate kinase def
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dec ATP
no Na/K ATPase -cell swelling and lysis |
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what can make sickle cell worse
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low O2
dehydration low pH |
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what is the defect in sickle cell
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substitution on glutamate for valine
defect in protein solubility |
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what is the metabisulfate test used for
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sickle cell
-dec pH causes sickling |
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HbC defect
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substitution of glutamate for lysine
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what is the defect in PNH
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impaired synthesis of GPI anchor
mutation in phosphotidylinositol glycan A |
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how can you Dx PNH
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Hams test
flocytometry |
