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56 Cards in this Set
- Front
- Back
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RLS in:
glycolysis |
PFK 1
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RLS in:
gluconeogenesis |
F16BP
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RLS in:
TCA |
isocitrate DH
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RLS in:
glycogen synthesis |
glycogen synthase
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RLS in:
glycogenolysis |
glycogen phosphorylase
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Diabetic drug:
lactic acidosis |
metformin
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Diabetic drug:
SE of hypoglycemia |
sulfonureas
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Diabetic drug:
MOA closes K channels |
sulfonureas
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Diabetic drug:
inhibits a-glucosidase |
acarbose
miglitol |
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Diabetic drug:
agonist at PPAR-y |
TZD
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what anticoagulant factors are dependent on vitamin K
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S
C |
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what coagulant factors are dependent on vitamin K
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10
9 7 2 |
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effects of bradykinen
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vasodilate
inc vascular permeability inc pain |
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labs used to monitor:
warfarin |
PT
INR |
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labs used to monitor:
heparin |
PTT
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labs used to monitor:
enoxaparin |
factor 10a activity
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Rx for HIT
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lapirudin
bivalirudin |
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what mineral is needed for coagulation
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Ca
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what can cause a decrease in Ca coagulation
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citrate
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in liver failure, which factor is lost first
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7
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MOA of acute hemolytic transfusion reaction
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recurrent meningiococcal infection due to hyperstabalized C3
deficiency on properdin -would normally cleave C3 |
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symptoms of clotting factor defect
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bleeding
hemarthrosis |
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symptoms of platelet defect
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patechiae
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what stimulates the release of factor 8 and vWF form endothelial cells
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desmopressin
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main symptom of hemophilia
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hemarthrosis
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lab changes in hemophilia
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inc PTT
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lab changes in vitamin K def
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inc PT and PTT
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prothrombin gene mutation
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G20210A
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what does AT3 normally activate
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7
9 10 11 12 |
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heparin given to AT3 def px
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reduced inc in PTT
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MOA of acute hemolytic transfusion reaction
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recurrent meningiococcal infection due to hyperstabalized C3
deficiency on properdin -would normally cleave C3 |
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symptoms of clotting factor defect
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bleeding
hemarthrosis |
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symptoms of platelet defect
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patechiae
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what stimulates the release of factor 8 and vWF form endothelial cells
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desmopressin
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main symptom of hemophilia
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hemarthrosis
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lab changes in hemophilia
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inc PTT
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lab changes in vitamin K def
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inc PT and PTT
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prothrombin gene mutation
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G20210A
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what does AT3 normally activate
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7
9 10 11 12 |
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heparin given to AT3 def px
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reduced inc in PTT
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liver makes all clotting factors except
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vWF
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D-dimers rise from the break down of
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fibrin
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FDP rise from the break down of
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fibrin or fibrinogen
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MOA of enoxaparin
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inhibit factor 10a
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MOA of heparin
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increase activation of AT
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MOA of HIT
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heparin binds to platelet factor 4 causing antibody production
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why are px with HIT hypercoagulable
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platelets are dropped but remaining ones are hyperactive
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MOA of argatroban
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directly inhibits thrombin
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when is lepirudin used
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px who take heparin and develops HIT
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MOA of warfarin
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inhibits epoxide reductase
-normally recycles vit K no more y-carboxylation of factors |
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what labs change with thrombolytics
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inc PT and PTT
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what is used in atrial fib
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warfarin
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what is used in STEMI
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thrombolytics
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MOA of thrombolytics
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increase conversion of plasminogen to plasmin
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name some thrombolytics
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streptokinase
urokinase alteplase (tPA) APSAC (anistreplase) |
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how does aminocaproic acid work
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inhibits fibrinolysis
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