Hematopoietic System (Path)

Front 1

What are the main components of hematopoietic system?

Back 1

cellular elements of blood
bone marrow
spleen
lymph nodes
thymus
Accessory lymphoid tissue

Front 2

What can be indications that there is a problem with the bone marrow?

Back 2

-unexplained cytopenias
-maturation defects of RBC -morphology abnormalities
-myeloproliferatice or lymphoproliferative disease
-malignancies

Front 3

What is the normal ratio of myeloid to erythroid cells in a bone marrow aspirate?

Back 3

1.5:1

Front 4

How does anemia affect the myeloid to erythroid ratio?

Back 4

Will see more erythroid cells

Front 5

How does inflammation affect myeloid to erythroid ratio?

Back 5

Will see more myeloid cells

Front 6

In a normal young animal what is the ratio of hematopoietic cells to fat?
How about in an adult?

Back 6

75% hematopoietic cells
25% fat

50/50

Front 7

What are three things that interfere with hematopoiesis?

Back 7

-radiation - most damage to cells with high mitotic rate
-chemicals
-viral infectious (feline panleukopenia, EIA, parvo)

Front 8

How can osteomyelitis effect bone marrow cell production?
What is often the cause of granulomatous osteomyelitis?

Back 8

pancytopenia

fungal infections

Front 9

What is the term for when myeloid tissue is replaced with collagen rich fibrous connective tissue?

Back 9

myelophthisis

this results in pancytopenia

Front 10

What are the gross findings of bone marrow hyperplasia?

Back 10

red marrow replacing yellow marrow

Front 11

What disease causes red marrow to replace yellow marrow?

Back 11

bovine leukocyte adhesion deficiency

leukocytes are unable to leave the site of inflammation so there are increased numbers in peripheral blood

Front 12

Myeloproliferative disease effect how many cell lines?

Back 12

one or more

this is not as common

Front 13

Lymphoproliferative diseases effect how many cell lines?

Back 13

just the lymphoid line and usually B cells

this is the most common

Front 14

Where do we see acute forms of myeloproliferative disease?

Back 14

in young dogs and cats

acute is rapidly fatal

chronic form is slow

Front 15

What are the three lymphoproliferative neoplasms?

Back 15

lymphoid leukemia
leukemic lymphoma
plasma cell myeloma

Front 16

What can you see in the liver and spleen of an animal with a lymphoproliferative disease?

Back 16

both organs become enlarged and friable

susceptible to trauma and can cause death

Front 17

What age do we see dogs and cats with multiple myeloma?

Back 17

between 8-9 years old

Front 18

What is the typical bone lesions seen with animals with multiple myeloma?

Back 18

osteomyelitis

Front 19

What are myelodystplastic syndromes?

Back 19

maturation abnormalities of marrow cells that are not neoplastic

Front 20

What can causes enlarged lymphnodes in horses?

Back 20

Strangles

called caseous lymphadenitis

Front 21

What causes granulomatous lymphadenitis in cattle?

Back 21

Mycobacterim bovis and fungal infections

Front 22

What disease can cause a diffuse granulomatous lymphadenitis in pigs?

Back 22

PMWS (porcine circovirus)

see botryoid intercytoplasmic inclusions on histology

Front 23

T/F

Lymphosarcoma is a secondary neoplasm.

Back 23

false

primary

one of the most common neoplasm of domestic animals

Front 24

What viruses can induce lymphosarcoma?

Back 24

FeLV - cats

bovine leukemia virus - bovine

Front 25

Where would you seen a multicentric lymphsarcoma?
Leukemic?

Back 25

peripheral and visceral also in spleen

in the blood

Front 26

What do you see with a thymic lymphosarcoma?

Back 26

seen in thymus - can compress the lungs
seen in younger animals

Front 27

Where what you see an alimentary lymphosarcoma?

Back 27

in the ileum at peyers patches

Front 28

What will a lymphosarcoma lymph node look like?

Back 28

It will be enlarged, lumpy with a capsule that adheres to the surrounding tissue

Front 29

What are the two most common tumors in pigs?

Back 29

lymphosarcoma
nephroblastoma

Front 30

What species do we seen siderotic plaques in a normal spleen?

Back 30

older dogs

Front 31

What are circulatory disturbances of the spleen?

Back 31

acute passive congestion
thrombosis, infarction
splenic rupture
splenic hematoma

Front 32

What are two causes of acute passive congestion of spleen?

Back 32

barbituates
gastroplenic torsion - seen in dogs and pigs

Front 33

What can splenic infacts in pigs be caused by?

Back 33

hog cholera (flavivirus family)
pestiviris - genus

Front 34

What part of the spleen would you find hyperplastic splenitis proliferation?

Back 34

White pulp looks nodular and can be caused by equine infectious arteritis

Front 35

What is your DDX in cattle with acute splenic hyperemia/splenitis?

Back 35

anthrax

Front 36

What can be a cause of necrotizing splenitis?

Back 36

Franciscella tularensis - gram negative, fastidious intracellular bacteria

"rabbit fever"

Front 37

How do raptors get herpes inclusion body disease?

Back 37

Consumption of infected pigeons

on histology you see eosinophilic intranuclear inclusion bodies

Front 38

What are secondary neoplasias of bone marrow?

Back 38

carcinoma
sacomas

Front 39

What bacteria can cause granulomatous splenitis?

Back 39

mycobacterium avium

Front 40

Where so we see thymic hypoplasia?

Back 40

in CID Arabian foals and Basset hounds

Front 41

What cancer of the thyroid do we seen in older animals and what disease is it associated with?

Back 41

thymoma
myesthenia gravis

Front 42

What are more common? thymic lymphomas or thymomas?

Back 42

Thymic lymphomas are more common

Front 43

Where do we see thymic lymphomas?

Back 43

in dogs cats and cattle