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6 Cards in this Set
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- Back
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Ferrous Sulfate: PO
Ferrous Gluconate: PO Iron Dextran: IV Iron Sodium Gluconate Complex: IV |
Uses: Iron deficiency anemia
Pharm: Fe2+ absorbed in duodenum & jejunum, txpted via transferrin, stored as ferritin, rarely eliminated. Effects: N/V/D, necrotizing gastroenteritis, hemochromatosis, metabolic acidosis, shock, coma (therapy with deferoxamine) |
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Deferoxamine: IM, IV
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Uses: iron poisoning (iron chelator)
MOA: binds & inactivates Fe molecule Effects: Neurotoxicity, ARDS, hypotension, allergic reactions |
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Folic Acid: PO
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Uses: Megaloblastic anemia due to folic acid deficiency, prevents NTD during pregnancy, For patients: dialysis, liver dz, phenytoin, MTX
Pharm: absorbed by proximal jejunum, + CSF, stored in liver FYI: converted to THF w/ vit. B12, needed for purine & DNA synthesis |
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Leucovorin (Folinic acid): PO
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Uses: MTX, TMP & pyrimethamine toxicities, increases Fluorouracil efficacy
Pharm: absorbed in small intestine FYI: THF cofactor, repletes folate pool |
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Cobalamin (vit. B12)
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Uses: Megaloblastic anemia due to impaired B12 absorption
Pharm: combines w/ intrinsic factor in distal ileum Effects: hypokalemia, thrombocytosis FYI: required in enzymatic rxns: N5 CH3-THF + homocysteine --> methionine + THF, CH3-malonyl CoA --> succinyl CoA, At risk for anemia: vegans, malabsorption syndromes, IBD, pernicious anemia |
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Erythropoietin
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Uses: anemias of chronic renal failure
Pharm: stimulation of erythroid proliferation & differentiation Effects: hypertension & thrombotic complications FYI: activates JAK/STAT receptors |
