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67 Cards in this Set
- Front
- Back
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spherocyte
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hereditoary spherocytosis
autoimmune hemolysis |
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elliptocyte
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hereditary elliptocytosis
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macro-ovalocyte
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megaloblastic anemia
marrow failure |
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hypersegmented PMNs
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megaloblastic anemia
B12 deficiency folate deficiency |
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helmet cell, schistocyte
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DIC
traumatic hemolysis |
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bite cell
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G6PD deficiency
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Teardrop cell
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myeloid metaplasia with myelofibrosis
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acanthocyte
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spiny appearance in abetalipoproteinemia
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target cell
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hbC disease
Asplenia Liver disease Thalassemia (HALT, said the hunter to his target) |
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pokilocytes
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nonuniform shapes in tTP/HUS
microvascular damage DIC |
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Burr cell
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TTP/HUS
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Basophilic stippling
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(TAIL)
Thalassemias Anemia of chronic disease Iron deficiency Lead poisoning |
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anemia with neurologic problems
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B12 deficiency
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crew cut on skull xray
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sickle cell anemia
thalassemias (crew cut is due to marrow expansion from increased erythropoiesis) |
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Cooms positive
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autoimmune hemolytic anemias
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Howell Jolly bodies after splenectomy
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Hereditary spherocytosis
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RBCs with no central pallor
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hereditary spherocytosis
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increased urine hemosiderin
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paroxysmal nocturnal hemoglobinuria
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schistocyte
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microangiopathic anemia (therefore DIC, TTP/HUS, SLE, malignant HTN)
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Reed Sternberg cells
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Hodgkin's disease (necessary but not sufficient)
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fried egg plasma cells
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multiple myeloma
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M spike
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Multiple myeloma
Waldenstrom's macroglobulinemia M spike is a monoclonal immunoglobulin spike on serum protein electrophoresis |
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Bence Jones protein
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Multiple myeloma
Bence Jones protein is Ig light chains in urine |
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rouleaux formation RBCs
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multiple myeloma
RBC's stacked like poker chips |
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starry sky
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Burkitt's lymphoma
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t(14;18)
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Follicular lymphoma (small cleaved cell)
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t(11;14)
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Mantle cell lymphoma
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t(8:14)
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Burkitt's lymphoma
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c-myc
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Burkitt's lymphoma
It moves to next to the heavy chain Ig gene on 14 |
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kid in Africa with big jaw lesion
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Burkitt's lymphoma
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t(9;22)
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CML- Philadelphia chromosome translocation in CML
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bcl-2
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Follicular lymphoma
moves from 14 to 18 in a translocation anti-apoptotic and gets activated |
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t(15;17)
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AML - M3 type
responsive to all-trans retinoic acid |
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t(11;22)
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Ewing's sarcoma
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TdT+
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marker of pre-T and pre-B cells;
ALL |
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warm antibody
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autoimmune hemolytic anemia
CLL |
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blast crisis
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CML shifting to AML
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TRAP+
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Hairy cell leukemia
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Auer bodies
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AML M3 (and DIC resulting from tx)
Auer bodies are peroxidase-positive cytoplasmic inclusions in granulocytes and myeloblasts Tx can release them and cause DIC |
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Birbeck granules
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Histiocytosis X
lung infiltrations that look like tennis rackets on EM |
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abl
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CML
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erb-B2
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breast, ovarian and gastric carcinomas
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ras
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colon carcinoma
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L-myc
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lung tumor
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N-myc
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neuroblastoma
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ret
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MEN II and III
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c-kit
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GIST (gastrointestinal stromal tumor)
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Rb gene (13q)
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reinoblastoma, osteosarcoma
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BRCA1
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breast and ovarian cancer
17q |
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BRCA2
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Breast cancer
17p |
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p53
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Most human cancers
Li-Fraumeni syndrome 9p |
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p16
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Melanoma
9p |
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APC
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melanoma
5q |
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WT1
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Wilms Tumor
17q |
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NF1 and NF2
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Neurofibromatosis type 1 and 2
11p and 17q, respectively |
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DPC
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pancreatic cancer
18q (with DCC) |
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DCC
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Colon cancer
18q (with DPC) |
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PSA
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Prostate carcinoma
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prostatic acid phosphatase
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marker for prostate carcinoma
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CEA
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Carcinoembryonic antigen
Nonspecific 70% of colorectal and pancreatic ca also gastric and breast carcinomas |
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alpha fetoprotein
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(normally made by fetus)
hepatocelllular carcinomas nonseminomatous germ cell tumors of testis (e.g., yolk sac tumor) |
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beta hCG
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HCG:
Hydatidiform moles Choriocarcinomas Gestational trophoblastic tumors |
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CA-125
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Ovarian -
malignant epithelial tumors |
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S-100
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Melanoma
neural tumors astrocytomas |
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alk-phos
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mets to bone
obstructive biliary disease Paget's disease of bone |
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Bombesin
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Neuroblastoma
lung and gastric cancer |
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CA-19-9
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Pancreatic adenocarcinoma
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