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10 Cards in this Set
- Front
- Back
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Heparin
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= bind ATIII -> dec thrombin and Xa
= short half-live = immediately active = safe in prego = follow PTT toxicity - osteoporosis and bleeding tx tox = Protamine sulfate (+ charged binds neg charge of heparin) |
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Enoxaparin
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= low molecular weight heparin
= act more on Xa = better bioavailablity and 2-4x longer half life = can administer subQ w/o monitoring = harder to reverse |
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HIT
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heparin induced thrombocytopenia
- heparin bind to PF4 on platelets - antibody production binds to and activates platelets leading to a thrombocytopenic HYPERCOAGUABLE STATE |
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leirudin
agratroban |
Hirudin dervative
- directly inhibits thrombin = use in pts that have HIT |
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bivalirudin
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hirudin deravitive
= directly inhbitis thrombin = use in pts w/ HIT |
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Warfarin toxicity signs
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= bleeding, teratogenic, skin/tissue necrosis, drug-drug interactions
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Warfarin vs Heparin inhibition in vitro
Site of action |
heparin still inhibits coagulation
warfarin does not Heparin: blood Warfarin: liver |
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Thrombolytics
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= streptokinase, urokinase, tPA (alteplase), APSAC (anistreplase)
= convert plasminogen to plasmin which then cleaves thrombin and fibrin clots = give in early MI and early Ischemic stroke Tx toxicity with = aminocaproic acid which inhibits fibrinolysis |
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ticlopidine
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block ADP receptors irreversibly
- prevent GpIIb/IIIa expression - use in acute coronary syndrome, coronary stenting, dec incidence or recurrence of thrombotic stroke - Toxicity = neutorpenia |
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Abciximab
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= monoclonal Ab that binds to gpIIb/IIIb receptor on activated platelets
= toxicity: bleeding thrombocytopenia |
