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40 Cards in this Set
- Front
- Back
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substances used to induce plt aggregation
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ristocetin, ADP, epinephrine, collagen, serotonin, thrombin
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what cells produce vWF?
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megakaryocytes and endothelial cells
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I
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fibrinogen
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II
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prothrombin
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III
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tissue thromboplastin / tissue factor
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IV
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ionized calcium
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V
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Proaccelerin / labile factor
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VII
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Proconvertin / stable factor
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VIII
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Antihemophilic Factor
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IX
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Plasma Thromboplastin Component / Christmas factor
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X
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Stuart-Prower Factor
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XI
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Plasma thromboplastin antecedent
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XII
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Hageman Factor
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XIII
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fibrin-stabilizing factor
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where does tissue factor come from?
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broken endothelium (not found in blood)
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GPIIb and GPIIIa allow plt-plt binding via what?
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fibrinogen
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factors in extrinsic system
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VII
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all necessary factors for fibrin formation are present where?
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in the blood
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intrinsic system factors
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VIII, IX, XI, XII
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common pathway factors
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I, II, V, X
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which factors are called co-factors?
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VIIIa and Va
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role of thrombin in coagulation
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XI -> XIa
VIII -> VIIIa V -> Va VII -> VIIa I -> fibrin XIII -> XIIIa plasminogen -> plasmin |
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activators of APTT
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silica, kaolin, celite
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source of tissue factor in APTT
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phospholipid
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Idiopathic Thrombocytopenic Purpura (ITP) is higher incidence in adults or children?
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children
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treatment for ITP
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splenectomy
corticosteroids |
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process of ITP
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Abs coat plts, which are then removed by spleen (autoimmune disorder)
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process of Drug Induced Immune Thrombocytopenia
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Ab produced against drug, Ab-drug complex attaches to plt, making Ab-drug-plt complex which is then removed by spleen
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example of drug that causes DIIT
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quinine
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process of Heparin Induced Thrombocytopenia (HIT)
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patients make Ab against heparin, this Ab promotes in vivo plt aggregation
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thrombotic thrombocytopenic purpura
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- decreased plt survival
- hyperplasia of plts in b.m. - N PT, APTT - typically affects adults |
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hemolytic uremic syndrome
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- renal failure
- commonly seen in children - N PT, APTT - dec. plts; schistocytes, polychromasia, inc. retics |
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DIC
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- inc. PT, APTT
- caused by sepsis, severe trauma, M3, dead fetus retention - inc. plt utilization - dec. fibrinogen |
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Glanzmann's Thrombastenia
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- problem with aggregation
- dec. amts. or dysfunctional GPIIb/IIIa receptor |
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Bernard Soulier Syndrome
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- problem with adhesion
- inadequate amts of GPIb receptor - large plts |
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1st category of vWD
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- 70% of all diseases
- mild bleeding - qualitative dec. in vWF |
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2nd category of vWd
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- 29%
- moderate bleeding - abnormality in structure of vWF |
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3rd category of vWD
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- absence of vWF
- severe bleeding |
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lab investigation of vWD
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- inc. bleeding time
- N PT - inc. APTT - N plt count - dec. VIII |
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treatment for vWD
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- administer DDAVP
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