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26 Cards in this Set

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What are lymphomas and how are they different from leukemias? What are 2 major types of lymphomas?
Lymphomas: solid tumors of lymphoid system (LN, tonsils, GI tract, spleen, liver). Not found in bone marrow like leukemias.
2 types: Hodgkin's and Non-Hodgkin's
Compare follicular vs. diffuse type NHL in terms of prognosis and cell type.
Follicular: better px -- difficult to cure but indolent course, B-cell type
Diffuse: agressive but 50% curable, either B or T-cell type
What is the genetic abnormality in follicular lymphoma (small cleaved cell)?
t (14;18)
bcl-2 expression (involved in apoptosis)
What is the most common lymphoma in children? in adults?
Children: lymphoblastic lymphoma
Adults: follicular lymphoma
How do lymphoblastic lymphoma patients present?
Presents with ALL and mediastinal mass (very aggressive)
What markers are seen in lymphoblastic lymphoma?
TdT and T-cell marker (T-cell type)
Burkitt's Lymphoma:
1) cell type?
2) linked to what virus?
3) difference b/w African vs. US form
1) B-cell
2) EBV
3) African: involves jaw
US: abdomen more common
Describe histology of Burkitt's
"starry sky pattern"
-- dark background of densely packed lymphocytes with light colored spots of macrophages
Genetic abnormality of Burkitt's
t (8;14)
c-myc gene fused to Ig heavy chain
What is cutaneous T-cell lymphoma (CTCL, mycosis fungoides)?
slowly progressive CD4+ T-cell lymphoma of skin, usually in elderly
Describe histology of CTCL
cerebriform nuclei (nuclei look like cerebral gyri)
Clinical presentation of CTCL
systemic erythroderma, erythematous and pruritic rash
Hodgkin's Lymphoma:
1) age distribution
2) gender
3) most commonly associated virus
1) bimodal
2) young men
3) EBV (up to 50%)
Presentation of HL
Constitutional si/sx: low grade fever, night sweats, weight loss, **in some pts, sx worsen with EtOH intake**
What is the distinctive tumor giant cell seen in HL?
Reed-Sternberg cells (binucleate giant cell -- owl eyes -- with eosinophilic inclusions
Name and describe a variant of R-S cell
Lacunar cell: mononucleated giant cell in nodular sclerosis
HL severity proportional to ____
number of R-S cells
Name 4 variants of HL
Lymphocyte predominant
Nodular sclerosing
Mixed cellularity
Lymphocyte depletion
Which HL variant is most common?
Nodular sclerosing
Which HL variant(s) have excellent prognosis?
Nodular sclerosing and lymphocyte predominant
Which HL variant(s) have poor prognosis?
Lymphocyte depletion
Which HL variant more common in women, primarily young adults?
Nodular sclerosing
Which HL variant in <35yo males?
Lymphocyte predominant
Which HL variant has most number of RS cells?
Mixed cellularity
Which HL variant(s) has lacunar cell RS variant?
Nodular sclerosing
Describe 4 clinical stages.
I: LN
II: >1 LN on same side of diaphragm
III: both sides of diaphragm
IV: disseminated, organ or extranodal tissue involved