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13 Cards in this Set

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What are characteristics of CML?
• a myeloproliferative disorder charcterized by overproduction of myeloid cells • has a specific chromosome abnormality, the Philadelphia chromosome
Describe each phase of CML
• Chronic phase: inactive, asymptomatic phase lasting 3-5 years • Accelerated phase: fever, weight loss, worsening splenomegaly, and bone pain related to rapid marrow cell turnover • Blast crisis: evolution to acute leukemia; marrow is replaces by blasts w/ loss of normal mature cellular elements in the marrow & periphery
True/False: Patients with CML will have a right-shift on a differentiated CBC
Patients with CML will have an increase in neutrophils & macrophages, which will cause a left-shift The correct answer is: False
What age group is typically affected by CML?
usually older patients (median age of onset is 55 y/o)
What are lab findings of a patient with CML?
• elevated WBC (usualy > 500,000) with a left-shift • bone marrow is hypercellular • presence of the Philadelphia chromosome
Acute Lumphoblastic leukemia (ALL) typically affects what age group?
children (90%)
Acute myelogenous leukemia typically affects which age group?
adults (90%)
What are characteristics of the acute leukemias?
• a malignancy of the hematopoietic progenitor cell • malignant cell loses its ability to mature & differentiate • malignant cells proliferate in an uncontrolled fashion and replace normal bone marrow elements
What are signs & symptoms of acute leukemia?
• bleeding (due to thrombocytopenia) • infection (due to neutropenia) • bone & joint pain • enlargement of the liver, spleen, & lymph nodes
What are lab findings of a patient with acute leukemia?
• a combination of pancytopenia with circulating blasts • bone marrow is hypercellular and dominated by blasts
Describe CLL
• a clonal malignancy of B lymphocytes • B cells respond poorly to antigens • manifested clinically by immunosupression, bone marrow failure, and organ infiltration with lymphocytes
CLL typically affects what age group?
older patients, with 90% of cases occuring after age 50
What is the classic laboratory findings of a patient with CLL?
Lymphocytosis (or a right-shift)