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18 Cards in this Set
- Front
- Back
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Rbc |
Carries oxygen which is attached to hemoglobin, returns CO2, blood pH |
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Erythropoiesis |
Process of maintaining adequate number of rbc in circulation |
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CFU-GEMM colony forming unit |
1st cytokine to start erythropoiesis |
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BFU-E |
Cytokine that produces large multiclustered colony, develops into CFU-E |
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CFU-E |
Many receptor sites for EPO, proliferate into pronormoblasts |
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Erythropoietin (EPO) |
Produced by kidney, prevents cell death of erythroid precursors, hgb synthesis |
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Pronormoblast - rubriblast |
Earliest recognizable cell |
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Basophilic normoblast - prorubricyte |
Chromatin begins to condense, deeper blue and maybe some patches of pink |
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Polychromatic normoblast - rubricyte |
Chromatin thickened and irregularly condensed, may be seen in newborns |
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Orthochromatic normoblast - metarubricyte |
Small and dense nucleus, DNA synthesis stops, hgb synthesis increases |
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Polychromatic erythrocyte - reticulocyte |
Nucleus extruded, basophilic, stain with new methylene blue to see retic.(RNA) |
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Normoblast stages |
65% hgb is made |
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Reticulocyte stages |
35% of hgb is made |
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Senescence |
At end of rbc 120 day life cycle rbc loses deformability and is destroyed |
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Extravascular destruction |
90% rbc destroyed by RE system |
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Intravascular destruction |
10% of rbc ruptures in bloodstream |
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Transferrin |
Carrier protein for returning iron to bone marrow |
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Rbc replacement |
1% removed daily and 1% replaced daily |
