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6 Cards in this Set
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78 yr old man, tingling and numbness of his hands/feet,alcoholic, MCV=110, HCT=30
Best Initial Step for Dx? |
Send for smear,
Diff b/w folate and B12 defi have hypersegmented neutrophil defi. Alcohol induced An,liver ds etc # hypersegmented neutrophil. >4 lobes=hypersegmented |
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Neurological problem
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Peripheral neuropathy Mcc
Anything like dementia,pychosis etc Shorter the duration of symptoms, greater the reversibility. |
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Diff b/w folate and B12 defi.
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B12= neuro Sx
folate= No Neuro Sx |
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Dx of B12 and folate defi
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B12 and folate levels.
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why inc. Methylmalonic acid level required?
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Trans-cobalmin can make B12 level artificially normal during stress etc.
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Schilling's test
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now replaced by Abs -Anti Intrinsic factor and Anti-Parietal cell Abs.
used to identify the etiology of B12 deficiency. |
