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14 Cards in this Set
- Front
- Back
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Microcytic Anemia
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dec. MCV,
Causes -Fe def anemia -sideroblastic anemia -Thalessimia ACD |
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Fe Def anemia(An)
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Malnurition
Hx of blood loss |
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Fe requirements
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Normal=1mg/day
female= 2-3mg/day pregnant= 5-6mg/day max absorption of Fe=4mg/day =>preg. will become An. |
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Case-
60 yr o->, w/ tiredness, Hct=30, Hct=68, Stool -ve X3 for blood. nxt best test? |
Colonoscopy
to rule out Ca Colon |
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Thalasemia minor-
Trait thalessimia |
most times symtoms r not felt
low. MCV High RBC count As high RBC compemstaes for low mcv so no Sx |
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in Thalasemia(major)-
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Hemochromatosis
fe built up in - Liver heart Pancrease testis *Transfused 2-4 units of blood |
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Tx thalasemia
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-Desferroximin
can't do phlebotomy as they are required to get transfused regularly. |
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ACD(anemia of chr ds)
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Any RA
Ca End stage renal ds |
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Sideroblastic An
cause |
Pb-lead
Alcohol-MCC Isoniazid |
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Microcytic Anemia-retic count
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Low reticulocyte count
Macro. An.-Low reticulo count Nomocytic- high reticulocytic count as there is no prob in production and bone marrow compensaqtes for the loss |
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Abnormal smear is present in which microcytic anemia
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Smear shows- Target cells
but they r not specific to thal. found in Liver ds also. Thalasa- sea, ds of people near sea- Sicilian and Mediterranean origin |
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RDW- Red cell distribution of width in diff Micro An
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RDW tells whether the cells are of same size of diff size.O0o= high RDW 000=low RDW
Fe def= Hi. RDW O0o due to low Fe ACD=All cels of same size=l. rdw Thal= all small as it is life long ds=low RDW |
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Fe studies
Ferritin- storage form |
(Only)low in Fe def An, dec storage form, low circulating Fe
Ferritin is acute phase reactant goes up in resp to stress , 1/3 norml in Fe def In ACD Fe is low but Ferritin is high due to infctn. |
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TIBC
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TIBC- Indirectly measures Transferrin(controlled by hepacidin)
Fe def= high as RBC are Empty ACD=Low TIBC(to prvent Fe from Organisms its hidden inside intercellular space by binding w/ ferritin, circulating transferrin dec.) Sideroblastic An- Normal Thalassaemia-Normal |
