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8 Cards in this Set

  • Front
  • Back
definition of anemia
decrease in the amount of oxygen reaching the tissues and organs of the body (hypoxia)
Severity of anemia depends on...
a. severity of anemia itself
b. speed of onset (acute blood loss, etc)
c. age and cardiovascular status
(very young & elderly more susceptible)
d. degree of reduction in O2 carrying capacity
Mechanisms of anemia (3)
1. decreased oxygen transport
(fatigue, syncope, dyspnea)
2. decreased blood volume
(pallor, postural hypotension)
3. increased cardiac output
(palpitations, congestive heart failure, heart murmurs)
Compensatory adjustments to anemia (6)
1. decreased O2 consumption
2. decreased O2 affinity (inc. 2,3-BPG)
3. increased tissue perfusion (blood moves from non-vital to vital organs)
4. increased cardiac output
5. increased pulmonary function
6. increased erythropoietic activity
Mean corpuscular volume (MCV)
average erythrocyte volume

MCV = (Hct(%)x10)/RBC count

ref range = 80-100 fL
Mean corpuscular hemoglobin (MCH)
average wt Hb in an erythrocyte

MCH - (Hb(g/dL)x10)/RBC count

ref range = 27-31 pg (picograms)

determines Normocytic, hypochromic, hyperchromic
DO NOT CALL VALUES >31 hyperchromic!
Mean corpuscular hemoglobin concentration (MCHC)
avg [Hb] in all RBC's

MCHC% = (Hb(g/dL)x100)/RBC count

ref range = 31-36%
general process to mechanism of anemia
a. proliferation defect: cells not being produced by bone marrow
b. maturation defect: cell made improperly
c. survival defect: mature cells unable to survive