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28 Cards in this Set
- Front
- Back
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general maturation in neutrophil lineage
morphologically similar to M2 dysplasia in neutrophil lineage |
t(8;21)
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morphologically similar to M4
increased and dysplastic eosinophils in BM increased incidence of extramedullary disease than other AMLs longer survival than AMLs |
t(16;16)
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associated with acute mono & myelo leukemia
pt may present DIC, extramedullary and/or tissue infiltration |
t(9;11)
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morphologically resembles M1 or M4
associated with basophilia and multilineage dysplasia children and adults pancytopenia poor prognosis |
t(6;9)
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rare
kids and adults typical morphology of lymphoblasts seen |
t(5;14)
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children, less often adults
blasts express cd 19, 10, and cytoplasmic mu heavy chains |
t(1;19)
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adults
worst of all ALLs |
t(9;22)
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infants
elevated WBC >100e9/L CNS involvement MLL gene on 11q23, many partners poor prognosis |
t(V,11q23)
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children
good prognosis rare in adults |
t(12;21)
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presents de novo
arises prior to MDS most common in adults morphologically resembles M1, M4, and M7. multilineage dysplasia especially platelets and megakaryocytes aggresive disease with short survival |
t(3;3)
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megakaryoblasts are prominent
female infants that are Down syndrome neg. hepatosplenomegaly |
t(1;22)
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AML with minimal differentiation
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M0
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AML with out maturation
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M1
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AML with maturation
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M2
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Acute Promyelocytic Leukemia
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M3
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Acute Myelomonocytic leukemia
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M4
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Acute Monoblastic and Monocytic Leukemia
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M5 (M5a and M5b)
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Erythroleukemia
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M6
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Acute Megakaryoblastic Leukemia
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M7
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CD 19, 34 pos
HLA-DR pos |
pro B-ALL
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CD 10, 19 pos
HLA-DR pos |
intermediate B-ALL
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CD 19 pos
HLA-DR pos Cytoplasmic Ig pos |
Pre B-ALL
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CD 7 pos
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T cell
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MPO/SBB pos
NSE neg |
M0,1,2,3
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MPO/SBB pos
NSE pos |
M4
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MPO/SBB neg
NSE pos |
M5
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NSE pos with acetate, not butyrate
PAS pos glycophorin A |
M6
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NSE pos with acetate, not butyrate
PAS pos PPO pos CD 41, 61 |
M7
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