Hematology Part 1 Final

Front 1

Blood constituants (blood & plasma) are:

Back 1

45% blood
55% plasma

Front 2

In myelopoiesis, which is the first stage to have non-specific granules?

Back 2

promyelocyte

Front 3

Where is EPO hormone created?

Back 3

kidney

Front 4

Which site is used most for adult BM biopsy?

Back 4

illian crest

Front 5

Name the order of granulocytopoiesis:

Back 5

myeloblast
promyelocyte
myelocyte
metamyelocyte
band

Front 6

N:C changes how as cell matures?

Back 6

ratio decreases (nucleus gets smaller)

Front 7

Does the hematology lab perform electrolyte studies?

Back 7

No

Front 8

Histocyte macrophages are located where?

Back 8

connective tissue

Front 9

In the fetus, the primary site of hematopoiesis is:

Back 9

liver

Front 10

Bands contain all ______ granules

Back 10

specific

Front 11

T cells mature in teh:

Back 11

thymus

Front 12

what are the 3 stromal elements of the hematopoeitic microenvironment?

Back 12

Fibroblasts
Macrophages
Adipocytes

Front 13

What is the first cell developed by the fetus?

Back 13

RBC

Front 14

Macrophages 2 main functions:

Back 14

remove debris
APC's

Front 15

BM biopsies from children are taken from:

Back 15

tibia

Front 16

Which erythroctye metabolic pathway generates ATP via glycolysis?

Back 16

Embden-Meyerhof

Front 17

What is the last RBC precurser stage is the last to undergo mitosis?

Back 17

polychromatophilic normoblast

Front 18

At high altitude, RBC's ____________

Back 18

increase

Front 19

Methgb contains:

The methgb reductase pathway is to maintain the __ form of Fe:

Back 19

ferric form of iron

the ferrous form of Fe.

Front 20

What are the 3 most important cell areas for RBC survival and function?

Back 20

RBC cell membrane
cell metaboilism
hgb structure

Front 21

The Rapoport Leubering shunt produces what?

What does this product aid in?

Back 21

2,3 DPG

Oxygen delivery to tissues

Front 22

What is teh most abundant of cells in teh PB?

Back 22

Neutrophils

Front 23

Plasma cells have what physical characteristic?

Reactive Lymphocytes show what smear characteristic?

Back 23

perinuclear halo

reactives: hug RBCs

Front 24

Hypersegmented neutrophils are associated with what anemia?

Back 24

megaloblastic anemia

Front 25

Howell Jolly bodies are made up of:

Back 25

DNA

Front 26

What protein transfers Fe throughout the body?

Back 26

Transferrin

Front 27

Megaloblastic anemia is considered a ____ , ___ anemia

Back 27

macrocytic, normochromic

Front 28

Anisocytosis:

What test measures this?

Back 28

size variations

RDW

Front 29

A normal hgb molecule is composed of:

Back 29

4 heme and 4 globin chains

Front 30

IDA & thallasemmia are considered ___ anemias:

Back 30

microcytic

Front 31

Chronic Liver Disease & B12 deficiency are considered ___ anemias:

Back 31

Macrocytic

Front 32

Hypochromic disorders are a qualitative or quantitative defect in hgb synthesis?

Back 32

QUANTITATIVE

Front 33

Spherocytes have what characteristic?

Back 33

no central pallor

Front 34

A "shift to the left" in the O curve of hgb is associated with what oxygen state?

Back 34

decreased oxygen release

Front 35

Acanthrocytes are associated with what cell trauma?

Back 35

membrane lipids

Front 36

Excessive Fe is called:

Back 36

hemochromatosis

Front 37

In ACD (anemia of chronic disease), serum Fe and transferrin will report out:

Back 37

Decreased serum Fe
Decreased transferrin

Front 38

G6PD deficiency and subsequent hemolysis occur bc of:

What cells are seen with G6PD deficiency?

G6PD deficiency is a ___ anemias:

Back 38

denatured hgb

Bite cells

Normocytic

Front 39

IDA will show increased levels of:

Back 39

TIBC

Front 40

Lead poisioning will show what inclusions?
What do these represent?

Back 40

basophilic stippling - ribosomes

Front 41

What inclusion cannot be seen under wrights stain?

Back 41

Heinz Bodies

Front 42

Ringed sideroblasts are usually due to abnormal :

Back 42

heme synthesis

Front 43

Where does heme synthesis occur in the cell?

Back 43

Mitochondria

Front 44

What is the main difference b/w ACD and IDA?

Back 44

ACD will have normal ferritin levels

Front 45

Low serum Fe will result in what level TIBC?

Back 45

Increased

Front 46

Sideroblastic Anemia:
Serum Fe levels?

Back 46

Increased serum Fe

Front 47

Anemia classifications are based on what tests?

Back 47

RBC indices

Front 48

Define pancytopenia:

Back 48

Decrease of all cells

Front 49

Which hgb is normal:
Carboxyhgb
sulfhgb
Deoxyhgb
methgb

Back 49

Deoxyhgb