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48 Cards in this Set
- Front
- Back
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The cleavage of the fibrin strand is called? |
Fibrinolysis |
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The action of antithrombin III is? |
Neutralizes thrombin and factors IXa, Xa, XIa, and XIIa |
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The final stage of hemostatic balance is? |
Fibrinolysis of the formed clot |
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Factor XIIa, HMWK and prekallikrein are classified as what? |
Serien proteases |
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The prothrombin group are dependent on the presence of 10 - 12 glutamic acid units on the N-termini. Production of these proteins in the liver is dependent on what nutritional component? |
Vitamin K |
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What factors are activated by thrombin? |
VII |
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What is a SERPIN? |
Serine Protease Inhibitors |
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What are some SERPINs associated with coagulation? |
alpha 1-antitripsin, antithrombin and heparin |
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What is secondary hemostasis? |
Activation of the coagulation system |
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Where are most of the coagulation factors symphasised? |
The liver |
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What factor binds readily after desqumaintion? |
??? |
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What is the factor that is a transglutamse and catlayses the cross linking of fibrin strands? |
Factor XIII |
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What is the target of VIIa? |
IX |
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Q13 |
Q13 |
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What dose the glutamic acid in prothrombin do?: |
Binds calcium |
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What kind of protean are most coagulation factors? |
Serene protease. |
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Q16 |
Q16 |
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How is protein C activated? |
binding of the thrombin-thrombomodulin complex |
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What is the function of Heparin? |
Increase the function of antithrombin III |
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What do the coagulation cascade co-factors do? |
Boost serene protease stability and function |
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What is targeted by the protein C-S complex? |
factor Va and VIIIa |
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What is the target of IXa? |
X |
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What inhibits the tissue factor path way? |
Binding of TFPI to the Xa-VIIa complex |
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What are the cogaulation co-factors? |
??? (Ca and vitamin K?) |
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What factor dose von Willebrand factor bind and why? |
VIII to increase how long it spend in the blood |
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What molecule is needed for a serene protease to function? |
calcium (Ca2++) |
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What is needed to activate factor X and what dose it do? |
Phospholipid, Ca2++ and Va
It's activation leads to the conversion of prothrombin to thrombin |
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How do endothelial cells prevent platelet adhesion? |
They secret prostacyclin |
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What happens during primary hemostasis? |
Vasoconstriction and the formation of a white platelet |
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What dose a serene protease need to bind in order to function? |
A negativley charged phospholipid surface |
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What factors are involved with the common coagulation path? |
X, V, prothrombin, firbinogin |
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Q31 |
Q31 |
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Q1 |
Q1 |
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A patient with the mutation Prothrombin G202010A is more likely to? |
Clot inapropriatly |
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Inthe presence of a lupus anticoagulant, the correction of the PTT activated by RVV or Kaolin is accomplished by the addition of? |
Excess phospholipids |
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What is the action warfarin? |
It is an antagonist for vitamin K |
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If a PTT is prolonged, the laboratorian may use DRVVT as the next diagnostic test. If the addition of normal plasma (mixing study 1:1) does not correct the PTT, it is likely that the patient has? |
A lupus anticoagulant |
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What is likely to happen in patients with factor V leiden mutation? |
They will clot inapporpiatly |
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What dose a high protein C concentration cause in a protein C clotting assay? |
A longer clot time |
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The condition in which fibrin microthrombi partially occlude small vessels and lead to consumption of platelet, coagulation factors, control proteins and fibrinolytic enzymes is? |
disseminated intravascular coagulation |
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One of the coagulation factors, if elevated, makes the blood more viscous which favors platelet activation and coagulation. That factor is? |
Fibrinogin |
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Patients with antiphospholipid antibodies will? |
Clot innapropriatly. |
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What factors dose antithrombin III neutralize? |
IXa, Xa, XIa, XIIa |
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What is likely to happen in patients with an antithrombin deficiency? |
Clotting |
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What is the function of protein S? |
Stabalize protein C |
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What is the function of the protein S-C complex? |
Inactivate Va and VIIa |
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What would be the result of a deficnecy in either protein S or C? |
bad clotting |
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ndji |
cbis |
