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19 Cards in this Set
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- Back
Localized bleeding (cause)
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injury in local area *surgical site, injury , infection, tumor
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Generalized Bleeding (cause) |
Systemic throughout body, multiple sites, spontaneous and recurring that need intervention and transfusions. Primary Hemostasis: blood vessels, plts, Secondary Hemostasis: coag mechanism |
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Acquired bleeding |
happens over time Take history--> CBC, plt count, pt, PTT FA. |
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Congenital bleeding |
Born with. Uncommon 1 in 100 Most common is deficiencies in VWD, VIII, IX. |
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Soft Tissue bleeding |
Generalized Acquired/Congenital Deficiency in coagulation factor bleeding may be: delayed, recurrent, spontaneous. internal in joints, cavities, muscles CNS Secondary hemostasis |
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Mucocutaneous |
Generalized Primary Hemostasis Small bleeds: purpura, petechiae, ecchymoses Platelets! prolonged bleeding time nosebleeds, gums, menstrual flow, vomiting blood |
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Trauma-Shock (ACOTS) |
Acquired Injury causes coagulopathy *Massive transfusion *Plt. decrease (mini vascular bleeds) Treat w/ FP, Plt (<50,000), Factor [ ] |
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Liver Disease |
Localized/General; Mucocutaneous/tissue Decrease in Vit. K dependent factors and Protein C,S,Z. Factor V: APR, Fibrinogen VIII and XIII Decrease in plts. Hepatosplenomegaly
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Liver Disease: Tests |
Fibrinogen: High than Low PT: prolonged PTT: depends on severity Hgb and Hem: Normal until bleeds Plt. could be decreased |
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Vitamin K |
Nutritional: feeding tubes, biliary obstruction, fat malabsorption, Ab. Hemorrhagic Disease of Newborns Antagonists: Warfarin, rat poisons |
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Vitamin K: Tests |
PT: prolonged PTT: pot. prolonged Mixing Study: correct w/ incubation 1 factor assays |
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Von Willebrand Factor |
Made in endothelial cells and megakaryocytes Promotes plt adhesion Carries Factor VIII |
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Clinical fetures |
Primary Hemostasis plts. Mucocutaneous bleeding. Dental, GI bleeding, leads to VIII deficiencies |
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VWD Type 1 |
Quantitative deficiency 70-80% of cases |
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VWD Type 2 |
Qualitative Disorders 20-30% |
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VWD Type 2 A |
10-20% Proteolysis forms small multimers --> decrease in adhesion |
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VWD Type 2 B |
<5% Binding to resting/normal plts. makes unavailable for adhesion. Thrombocytopenia |
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VWD Type 2 M |
RARE Lap 1B cannot bind |
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VWD Type 2 N |
Autosomal Hemophilia RARE impaired factor VIII binding site |