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6 Cards in this Set

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Heparin

1) Activates the formation of ______ and lowers levels of Factor __ , ___ and _____

2)Use and Test to follow dose

3)Toxicity

4)Trt if overdosed

5)Administration
1)Antithrombin III, factor Xa,XI, and XII

2)Used for immediate anitcoagulation in strokes, PE, MI, DVTs. Follow PTT

3)Bleeding, Thrombocytopenia, Drug Drug Interactions

4) Protamine Sulfate

5) Injection

DOESN'T CROSS PLACENTA
Warfarin (Coumadin)

1)Interferes with _____ dependent factors by inhibiting ________ reaction

2)Lowers Factors ___, ___, ___, and ___

3) Monitor dose with

4) Use

5) Toxicity

6)Notes

7)Antidote
1) Vit K, gamma-carboxylation

2) II, VII, IX, X

3) PT (extrinsic pathway)

4) Chronic Anticoagulation (long half life) but not in pregnancy

5)Bleeding, Teratogenic

6)Must give Heparin when starting because it takes 2-3 days for newly synthesized factors without carboxylation are in system

7) Fresh Frozen Plasma and Vit K
Thrombolytics (Streptokinase, tPA)

1)MOA
2)Use
3)Toxcity
4)Antidote
1) Directly or indirectly convert plasminogen--> plasmin which cleaves thrombin/fibrin clots

2) Early MI, Early Strokes

3) Bleeding...can't be used in pts with hx of bleeding disorders, hypertension, intracranial bleeds, recent surgery

4) Aminocaproic acid --> inhibits formation of plasmin
Aspirin

1)MOA
2)Use
3)Toxicity
1) Acetylates and irreversibly inhibits COX1 and COX2 to prevent Prostaglandin synthesis (no TXA2 for platelet reaction)
No effect on PT, PTT

2) Antipyretic (blocks IL-1), Analgesic, Anti-inflammatory, antiplatelet

3)Gastric Ulcers (Type A) because it decreases protective mucous, bleeding, hyperventilation (causes Met Acidosis), Reye's Syndrome (fatty liver and brain), Tinnitus
Clopidogrel, Ticlopidine

1)MOA
2)Use
3)Toxicity
1)Block plately aggregation by irreversibly blocking ADP receptors, and inhibits glycoprotein IIb/IIIa expression (no fibrin cross links)

2) Coronary Syndrome (various MI's), stenting, lower incidence of thrombotic stroke

3) Neutropenia
Abciximab

1)MOA
2)Use
3)Toxicity
1)Monoclonal Ab that binds IIb/IIIa receptor to prevent plately aggregation

2)Acute Coronary Syndrome, Percutaneous Transluminal Coronary Angioplasty

3)Bleeding, Thrombocytopenia