Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
Heparin
1) Activates the formation of ______ and lowers levels of Factor __ , ___ and _____ 2)Use and Test to follow dose 3)Toxicity 4)Trt if overdosed 5)Administration |
1)Antithrombin III, factor Xa,XI, and XII
2)Used for immediate anitcoagulation in strokes, PE, MI, DVTs. Follow PTT 3)Bleeding, Thrombocytopenia, Drug Drug Interactions 4) Protamine Sulfate 5) Injection DOESN'T CROSS PLACENTA |
|
|
Warfarin (Coumadin)
1)Interferes with _____ dependent factors by inhibiting ________ reaction 2)Lowers Factors ___, ___, ___, and ___ 3) Monitor dose with 4) Use 5) Toxicity 6)Notes 7)Antidote |
1) Vit K, gamma-carboxylation
2) II, VII, IX, X 3) PT (extrinsic pathway) 4) Chronic Anticoagulation (long half life) but not in pregnancy 5)Bleeding, Teratogenic 6)Must give Heparin when starting because it takes 2-3 days for newly synthesized factors without carboxylation are in system 7) Fresh Frozen Plasma and Vit K |
|
|
Thrombolytics (Streptokinase, tPA)
1)MOA 2)Use 3)Toxcity 4)Antidote |
1) Directly or indirectly convert plasminogen--> plasmin which cleaves thrombin/fibrin clots
2) Early MI, Early Strokes 3) Bleeding...can't be used in pts with hx of bleeding disorders, hypertension, intracranial bleeds, recent surgery 4) Aminocaproic acid --> inhibits formation of plasmin |
|
|
Aspirin
1)MOA 2)Use 3)Toxicity |
1) Acetylates and irreversibly inhibits COX1 and COX2 to prevent Prostaglandin synthesis (no TXA2 for platelet reaction)
No effect on PT, PTT 2) Antipyretic (blocks IL-1), Analgesic, Anti-inflammatory, antiplatelet 3)Gastric Ulcers (Type A) because it decreases protective mucous, bleeding, hyperventilation (causes Met Acidosis), Reye's Syndrome (fatty liver and brain), Tinnitus |
|
|
Clopidogrel, Ticlopidine
1)MOA 2)Use 3)Toxicity |
1)Block plately aggregation by irreversibly blocking ADP receptors, and inhibits glycoprotein IIb/IIIa expression (no fibrin cross links)
2) Coronary Syndrome (various MI's), stenting, lower incidence of thrombotic stroke 3) Neutropenia |
|
|
Abciximab
1)MOA 2)Use 3)Toxicity |
1)Monoclonal Ab that binds IIb/IIIa receptor to prevent plately aggregation
2)Acute Coronary Syndrome, Percutaneous Transluminal Coronary Angioplasty 3)Bleeding, Thrombocytopenia |
