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18 Cards in this Set
- Front
- Back
what cell type is the problem in most lymphomas?
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B cells
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which are the precursor B cell neoplasms?
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B lymphoblastic leukemia/lymphoma
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which are the pre-germinal center neoplasms?
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mantle cell lymphoma
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which are the germinal center neoplasms?
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- follicular lymphoma
- Burkitt lymphoma - Diffuse large B cell lymphoma - Hodgkin's lymphoma |
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what are the post-germinal center neoplasms?
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- marginal zone and MALT lymphomas
- lymphoplasmactyic lymphoma - CLL/SLL - Diffuse Large B cell lymphoma - plasma cell myeloma |
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what is the most common leukemia of adults in western countries?
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chronic lymphocytic leukemia
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what age group is most affected by chronic lymphocytic leukemia?
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older people; median age is 65
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what part of the spleen does CLL predominantly involve?
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white pulp
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what are the 3 possible progressions of CLL?
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- when greater than 55% of neoplastic cells are composed of prolymphoctes the prognosis is poor usually death soon
- progression to B cell lymphoma - progression to Hodgkin's lymphoma |
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what are the major B cell markers?
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CD20, CD22, CD5
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what are the 2 categories of CLL based on genetics?
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- mutated state: when the Ig heavy chain is hypermutated
- nonmutated state: when the Ig heavy chain is unmutated |
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which has a better prognosis, the mutated or unmutated CLL?
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mutated
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a patient is known to have CLL. what can you test for to determine if they have the mutated or unmutated state?
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ZAP 70 which is associated with the unmutated genotype
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a patient's B cell neoplasms is positive for CD10. what is the most likely diagnosis?
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follicular lymphoma
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a patient's B cell neoplasms is positive for CD25/C103. what is the most likely diagnosis?
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hairy cell leukemia
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a patient's B cell neoplasm is positive for FMC-7. what is the most likely diagnosis?
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prolymphocytic leukemia
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a patient's B cell neoplasm is positive for cyclin D1. what is the most likely diagnosis?
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mantle cell lymphoma
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what is rituximab?
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a monoclonal antibody against CD20
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