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18 Cards in this Set

  • Front
  • Back
what cell type is the problem in most lymphomas?
B cells
which are the precursor B cell neoplasms?
B lymphoblastic leukemia/lymphoma
which are the pre-germinal center neoplasms?
mantle cell lymphoma
which are the germinal center neoplasms?
- follicular lymphoma
- Burkitt lymphoma
- Diffuse large B cell lymphoma
- Hodgkin's lymphoma
what are the post-germinal center neoplasms?
- marginal zone and MALT lymphomas
- lymphoplasmactyic lymphoma
- CLL/SLL
- Diffuse Large B cell lymphoma
- plasma cell myeloma
what is the most common leukemia of adults in western countries?
chronic lymphocytic leukemia
what age group is most affected by chronic lymphocytic leukemia?
older people; median age is 65
what part of the spleen does CLL predominantly involve?
white pulp
what are the 3 possible progressions of CLL?
- when greater than 55% of neoplastic cells are composed of prolymphoctes the prognosis is poor usually death soon

- progression to B cell lymphoma

- progression to Hodgkin's lymphoma
what are the major B cell markers?
CD20, CD22, CD5
what are the 2 categories of CLL based on genetics?
- mutated state: when the Ig heavy chain is hypermutated

- nonmutated state: when the Ig heavy chain is unmutated
which has a better prognosis, the mutated or unmutated CLL?
mutated
a patient is known to have CLL. what can you test for to determine if they have the mutated or unmutated state?
ZAP 70 which is associated with the unmutated genotype
a patient's B cell neoplasms is positive for CD10. what is the most likely diagnosis?
follicular lymphoma
a patient's B cell neoplasms is positive for CD25/C103. what is the most likely diagnosis?
hairy cell leukemia
a patient's B cell neoplasm is positive for FMC-7. what is the most likely diagnosis?
prolymphocytic leukemia
a patient's B cell neoplasm is positive for cyclin D1. what is the most likely diagnosis?
mantle cell lymphoma
what is rituximab?
a monoclonal antibody against CD20