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26 Cards in this Set
- Front
- Back
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What is the survival rate for patients with brain stem glioma?
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< 5 %
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What is the survival rate for patients with medulloblastoma?
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30 % for metastatic disease and 85% for standard-risk localized disease
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What is the survival rate for patients with ependymoma?
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50 % survival if complete resection is obtained
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Where do ependymoma's typically present?
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at the base of the posterior fossa/top of the spinal cord, or abutting, but not invading the brain stem.
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What are average retic counts in infants?
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5%
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Where is the first site of red blood cell formation?
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Yolk sac at 2 weeks gestation
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Where is red blood cell formation in utero?
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yolk sac - 2 wk gest
liver - 8 w - 5 mo gest bone marrow 5 mos on |
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What is average hemoglogin in a newborn?
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17 g/dL
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What is the average hemoglobin level at physiologic nadir?
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9-11 g/dL
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What is the lifespan of a mature red cell?
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120 days
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What type of anemia is associated with hypothyroidism, Addison disease, hypogonadism and or panhypopituitarism?
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Hypoproliferative anemia
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When should iron suplementation be provided in term and preterm infants?
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1 mg/kg/day for exclusively breastfed infants starting at 6 mos. Preemies 1-2 mos of age.
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What is the single most common childhood malignancy?
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Acute lymphoblastic leukemia
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When is the peak incidence of ALL?
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2 and 5 years of age
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What is the annual incidence of ALL?
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3/100,000
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What disordered are associated with increased risk of ALL?
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Down Syndrome
Ataxia-telangiectasia Bloom syndrome Fanconi anemia |
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What is the most common presentation of ALL?
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4 P's
Pallor Pyrexia Purpura Pain |
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What should you think if there is a limping 3 year old with pallor?
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ALL
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What percentage of patients with ALL have generalized lymphadenopathy HSM.
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50%
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What is the most common lab presentation with ALL?
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Normocytic, normochromic anemia and reticulocytopenia
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What is necessary to make a diagnosis of acute leukemia?
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25% blast cells on bone marrow aspirate.
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85% of ALL develops from monoproliferation of what type of cell line?
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B-cell precursors
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What is FAB L1 classification of ALL?
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The most common form of leukemia in childhood. (lymphoblast are small with a small nucleolus)
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What is FAB L2 classification of ALL?
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Present in 2/3 of adult ALL but only 14% in kids. Blasts are more than twice the diameter of normal lyphocytes.
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What is the FAB L3 classification of leukemia?
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Leukemic for of Burkitt lymphoma and has the same t(8,14) translocation
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What are good prognostic indicators for ALL?
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- rapid response to treatment
- hyperdiploidy - the t(12:21) translocation - female sex - FAB L1 subtype |
