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38 Cards in this Set
- Front
- Back
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What is Factor I?
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Fibrinogen
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What is Factor II?
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Prothrombin
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What is Factor III?
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Tissue Thromboplastin, Tissue Factor
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What is Factor IV?
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Ionized Calcium
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What is Factor V?
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Labile factor, Proaccelerin
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What is factor VI?
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Not assigned
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What is Factor VII?
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Stable Factor, Serum prothrombin conversion acceleration (SPCA), Proconvertin
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What is Factor VIII?
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Antihemophilic factor A (VIII:C [VIII:AHF] is the coagulant portion; VIII:vWF is von Willebrand portion)
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What is Factor IX?
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Christmas factor, PLasma thromboplastin component, PTC, Antihemophilic factor B
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What is Factor X?
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Stuart-Prower Factor
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What is Factor XI?
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Plasma thromboplastin antecedent, PTA
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What is Factor XII?
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Fibrin-stabilizing factor (FSF)
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What is Fitzgerald Factor?
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High-molecular-weight-kininogen (HMWK)
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What is Fletcher Factor?
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Prekallikrein (PK)
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What are the 3 categories, when blood coagulation factors are grouped by function and which factors are in each category?
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Substrate(I)
Cofactors (V, VIII:C) Enzymes; Proteases (II, VII, IX, X, XI, XII, and Prekallikrein), Transaminases (XIIIa). |
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What are the 3 categories, when blood agglutination factors are grouped by Physical factors?
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Fibrinogen Group, Prothrombin Group, and Contact Group
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What factors and characteristics make-up the Fibrinogen Group?
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Factors; I, V, VIII, XIII.
Characteristics; High-Molecular-Weight Protiens, found in platelets, acted on by thrombin, consumed during coaggulation, and are not Vitamin K-dependent for synthesis. |
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What factors and characteristics make-up the Prothrombin Group?
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Factors; II, VII, IX, X
Characteristics; Low-Molecular-Weight Proteins, contain gamma carboxyglutamic acid, not consumed during coagulations, Vitamin K-dependent for synthesis. |
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What factors and characteristics make-up the Contact Group?
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Factors; XII, XI, PK, HMWK
Characteristics; Involved in the initial phase of intrinsic system activation, not consumed during coagulation, and is not Vitamin K-dependent for synthesis. |
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What is the only factor deficiency that would be seen in the Extrinsic Pathway?
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Factor VII.
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What activates the Extrinsic Pathway?
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Factor III
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What activates the Intrinsic Pathway?
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Collagen
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What chelator is used in the laboratory evaluation of hemostatic disorders, specifically in blood sample preparation?
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Sodium Citrate (occasionally serum)
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What lab test is done to evaluate the Extrinsic and Common pathways?
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One-stage prothrombin time (PT)
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What reagent is used, factors tested for, and normal test value in the PT test?
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Thromboplastin-calcium reagent Factors; I, II, V, VII, X
Normal; 11-13 seconds |
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What lab test is done to evaluate the Intrinsic and Common pathways?
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Activated partial thromboplastin time (APTT or PTT)
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What reagent is used, factors tested for, and normal value in the APTT or PTT test?
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Partial Thromboplastin (PF 3 substitute) and calcium reagent
Factors; I, II, V, VIII, IX, X, XI, XII Normal; <35 seconds |
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Name all activators that can initiate the intrinsic pathway?
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Celite, Kaolin, Diatomaceous Earth, Glass and Collagen.
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What two lab tests are done for conversion of fibrinogen to fibrin?
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Thrombin time and Quantitative fibrinogen assay
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What reagent is used in and the normal value of the Thrombin time test?
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Thrombin reagent, no calcium
Normal; 10-15 (15-22) seconds |
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What is the normal value in the Quantitaive Fibrinogen Assay?
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200-400 mg/dL
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What does the Thrombin Time test for?
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Low or dysfunctional fibrinogen, heparin, excess plasmin.
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Describe the lab evaluation used for Factor XIII activity.
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Observe fibrin stabilized clot in 5M Urea over time.
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Name the 3 acquired coagulation defects?
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Vitamin K deficiency, Heparin Therapy (anti-thrombin), and Acute Disseminated Intravascular Clotting (DIC)
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Name the 4 hereditary coaggulation defects.
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Classic Hemophilia A (Factor VIII:C deficiency)
von Willebrand's Disease (Factor VIII:vWF deficiency) Hemophilia B/ Christmas Disease (Factor IX deficiency) Rare Deficiencies (Factors I, II, V, VII, X, XII) |
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Describe the lab test for Fibrinolysis and what it is testing for.
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Latex bead agglutination with D and E fragment Ab's on latex beads, if these fragments are present, agglutination occurs. Tests for Fibrin(ogen) split products, i.e. FSP or FDP
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What are the causes of a defect in primary fibrinolysis?
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Massive Strep. Infections producing streptokinases
Kidney cancers producing urokinases Trauma (crush) acidents |
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What does a defect in primary fibrinolysis result in?
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Fibrin/Fibrinogen Split products and Decreased Factors V and VIII:C
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