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38 Cards in this Set

  • Front
  • Back
What is Factor I?
What is Factor II?
What is Factor III?
Tissue Thromboplastin, Tissue Factor
What is Factor IV?
Ionized Calcium
What is Factor V?
Labile factor, Proaccelerin
What is factor VI?
Not assigned
What is Factor VII?
Stable Factor, Serum prothrombin conversion acceleration (SPCA), Proconvertin
What is Factor VIII?
Antihemophilic factor A (VIII:C [VIII:AHF] is the coagulant portion; VIII:vWF is von Willebrand portion)
What is Factor IX?
Christmas factor, PLasma thromboplastin component, PTC, Antihemophilic factor B
What is Factor X?
Stuart-Prower Factor
What is Factor XI?
Plasma thromboplastin antecedent, PTA
What is Factor XII?
Fibrin-stabilizing factor (FSF)
What is Fitzgerald Factor?
High-molecular-weight-kininogen (HMWK)
What is Fletcher Factor?
Prekallikrein (PK)
What are the 3 categories, when blood coagulation factors are grouped by function and which factors are in each category?
Cofactors (V, VIII:C)
Enzymes; Proteases (II, VII, IX, X, XI, XII, and Prekallikrein), Transaminases (XIIIa).
What are the 3 categories, when blood agglutination factors are grouped by Physical factors?
Fibrinogen Group, Prothrombin Group, and Contact Group
What factors and characteristics make-up the Fibrinogen Group?
Factors; I, V, VIII, XIII.
Characteristics; High-Molecular-Weight Protiens, found in platelets, acted on by thrombin, consumed during coaggulation, and are not Vitamin K-dependent for synthesis.
What factors and characteristics make-up the Prothrombin Group?
Factors; II, VII, IX, X
Characteristics; Low-Molecular-Weight Proteins, contain gamma carboxyglutamic acid, not consumed during coagulations, Vitamin K-dependent for synthesis.
What factors and characteristics make-up the Contact Group?
Factors; XII, XI, PK, HMWK
Characteristics; Involved in the initial phase of intrinsic system activation, not consumed during coagulation, and is not Vitamin K-dependent for synthesis.
What is the only factor deficiency that would be seen in the Extrinsic Pathway?
Factor VII.
What activates the Extrinsic Pathway?
Factor III
What activates the Intrinsic Pathway?
What chelator is used in the laboratory evaluation of hemostatic disorders, specifically in blood sample preparation?
Sodium Citrate (occasionally serum)
What lab test is done to evaluate the Extrinsic and Common pathways?
One-stage prothrombin time (PT)
What reagent is used, factors tested for, and normal test value in the PT test?
Thromboplastin-calcium reagent Factors; I, II, V, VII, X
Normal; 11-13 seconds
What lab test is done to evaluate the Intrinsic and Common pathways?
Activated partial thromboplastin time (APTT or PTT)
What reagent is used, factors tested for, and normal value in the APTT or PTT test?
Partial Thromboplastin (PF 3 substitute) and calcium reagent
Factors; I, II, V, VIII, IX, X, XI, XII
Normal; <35 seconds
Name all activators that can initiate the intrinsic pathway?
Celite, Kaolin, Diatomaceous Earth, Glass and Collagen.
What two lab tests are done for conversion of fibrinogen to fibrin?
Thrombin time and Quantitative fibrinogen assay
What reagent is used in and the normal value of the Thrombin time test?
Thrombin reagent, no calcium
Normal; 10-15 (15-22) seconds
What is the normal value in the Quantitaive Fibrinogen Assay?
200-400 mg/dL
What does the Thrombin Time test for?
Low or dysfunctional fibrinogen, heparin, excess plasmin.
Describe the lab evaluation used for Factor XIII activity.
Observe fibrin stabilized clot in 5M Urea over time.
Name the 3 acquired coagulation defects?
Vitamin K deficiency, Heparin Therapy (anti-thrombin), and Acute Disseminated Intravascular Clotting (DIC)
Name the 4 hereditary coaggulation defects.
Classic Hemophilia A (Factor VIII:C deficiency)
von Willebrand's Disease (Factor VIII:vWF deficiency)
Hemophilia B/ Christmas Disease (Factor IX deficiency)
Rare Deficiencies (Factors I, II, V, VII, X, XII)
Describe the lab test for Fibrinolysis and what it is testing for.
Latex bead agglutination with D and E fragment Ab's on latex beads, if these fragments are present, agglutination occurs. Tests for Fibrin(ogen) split products, i.e. FSP or FDP
What are the causes of a defect in primary fibrinolysis?
Massive Strep. Infections producing streptokinases
Kidney cancers producing urokinases
Trauma (crush) acidents
What does a defect in primary fibrinolysis result in?
Fibrin/Fibrinogen Split products and Decreased Factors V and VIII:C