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17 Cards in this Set
- Front
- Back
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List the four interrelated systems that have a role in hemostasis
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blood vessels, platelets, blood coagulation factors, and component of the clot dissolution system
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Describe the blood vessels' role in hemostasis
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when a blood vessel is damaged, this causes vasoconstriction and helps to reduce flow to the area.
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What protein connective tissue is exposed when the lining of the blood vessels is damaged?
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Collagen
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Outline the role of platelets in clot formation.
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Collagen exposed in vessel of lining, platelet adhesion, and platelet aggregation
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What is the role of the coagulation factors in hemostasis?
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help to form a fibrin clot
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What are the coagulation factors that are vitamin K dependent?
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factors II, VII, IX, and X
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Explain how atherosclerosis can cause thrmbus formation
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Blood vessel walls become rough and irregular. This can cause platelets to become activated and initiate the formation of clots within the blood vessels.
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What are the two components in fibrinolytic system?
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plasminogen and plasmin
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What are the three pathways in coagulation cascade and the factors involved in each?
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Extrinsic Pathway--> factor III
Intrinsic Pathway--> what is present in your blood Common Pathway--> result of intrinsic or extrinsic pathway |
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What types of blood specimans can be used for coagulation testing?
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Plasma
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Name two inherited disorders of platelets
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von Willebrand's disease and Bernard-Soulier Syndrome
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Name two acquired disorders of platelets
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aspirin ingestion and decreased megakaryocyte prodution
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What is the difference between Hemophilia A and B?
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A-- deficiency of factor VIII
B-- deficiency of factor IX |
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What is Prothrombin Time?
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a coagulation screening test used to monitor oral anticoagulant therapy
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What is the reference value for the ProTime test? For the INR?
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10-13 seconds and between 1.0-1.4
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What are the three ways that a ProTime test can be reported?
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In seconds, ProTime ratio, or the INR
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What anticoagulant is used to collect blood for a ProTime test?
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3.2% solution of Sodium Citrate
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