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29 Cards in this Set
- Front
- Back
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Ig produced by MM cells is called ___ (2)
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M protein
paraprotein |
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IL-___ is implicated in MM
it is secreted by ___ (5) |
6
plasma cells fat cells fibroblasts osteoclasts osteoblasts |
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5 cytokines causing adherence of MM cells to stroma
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IGF
TGFb FGF IL-6 RANKL |
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MM incidence is high in ___ (ethnicity) and low in ___ (ethnicity)
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african american
asian |
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3 environmental factors in MM
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radiation
heavy metals pesticides |
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virus associated with MM
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HHV8
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average age of onset of MM
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65
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most common presentation of MM
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anemia of chronic disease
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criteria for MGUS
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M protein < 3 g%
<10% plasma cells in BM no other MM symptoms |
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3 MM diagnostic factors
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CRP
beta2 microglobulin chromosomal changes |
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MM chromosomal changes
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11q
14q monosomy 13 hypodiploidy |
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3 major MM criteria
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>30% plasma cells in BM
IgG>3.5g% or IgA>2g% BJ > 1g/day |
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4 minor MM criteria
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10-29% plasma cells in BM
M protein below major criteria lytic lesions on X ray hypogammaglobulinemia |
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to dx MM you need ___ (2) or ___
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1 major
1 minor 3 minors |
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anemia in MM is txed with
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EPO
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skeletal symptoms in MM are treated with ___ (3)
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radiation
bisphosphonates pain control |
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infection in MM is txed with __ (2)
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prophylactic antibiotics
IVIg |
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conventional chemo for MM is ___ (2)
combination chemo is ___ (3) these are sometimes combined with ___ |
melphalan
prednisone vincristin adriamycin prednisone thalidomide |
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relapse after autologous SC transplant is ___.
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inevitable
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thalidomide causes increased ___ and decreased ___ (3)
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IFNg
TNF VEGF IL-6 |
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bortezomib is a ___ inhibitor and prevents ___ by ___ing.
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proteasome
signalling through NFkB inhibiting degradation of IkB |
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monoclonal peak in MM is due most commonly to ___ followed by ___ and ___.
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IgG
IgA LC |
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in MM BM shows ___
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>10% plasma cells
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___ may cause neurological symptoms in MM
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vertebral collapse
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bone disease in MM is caused by ___ (3)
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TNF
IL-1beta IL-6 |
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in renal failure due to MM you get ___calcemia and ___uricemia
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hyper
hyper |
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___ is used to block inflammatory cytokines released by ___ in response to ___
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PACAP-38
renal PT epithelium light chain |
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most common complication of MM is ___, followed by ___.
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osteolytic lesions
hypercalcemia |
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solid mass of MM cells is called ___
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plasmacytoma
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