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30 Cards in this Set
- Front
- Back
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CLL is ___. SLL is ___. MBL is ___
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chronic lymphocytic leukemia
small lymphocytic leukemia monoclonal B cell lymphocytosis |
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5 markers for monoclonal B lymphocytosis
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CD5
CD19 CD23 SmIg weak CD20 weak |
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if B cell count with markers is >___, it's ___.
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5000/uL
CLL |
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3 criteria for SLL
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<5000 cells/uL
enlarged liver/spleen enlarged LNs |
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if any of the SLL criteria fail to obtain, dx is ___
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MBL
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___% of CLL pts are asymptomatic at dx
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40
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when symptomatic CLL presents with ___
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fatigue
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CLL lymphocytes are mature/immature
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mature
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level of ___ in CLL correlates with severity of disease
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beta2 microglobulin
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___ cells are classic marker for CLL
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smudge
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___ is done to confirm dx of CLL
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immunophenotyping
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CLL cells may express ___ on membrane
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Ig light chain
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___gammaglobulinemia is characteristic of CLL
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hypo
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10-25% of CLL pts develop ___ or ___
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AIHA
ITP |
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in CLL >___% of nucleated cells in BM aspirate are lymphoid
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30
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2 genes implicated in CLL
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p53
ATM |
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p53 is on chromosome ___
ATM is on chromosome ___ |
17p
11q |
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in CLL, ATM mutations are associated with ___
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lymphadenopathy
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in CLL, p53 mutations are associated with ___
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resistance to tx
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another bad cytogenetic marker in CLL is ___
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unmutated V_H
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2 markers that correlate with V_H mutation status
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ZAP-70
CD38 |
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ZAP-70 is a ___ expressed in B CLL cells
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Y kinase
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in addition to cytogenetic markers, ___ (3) are prognostic factors
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age
lymphocyte count LDH |
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2 alkylating agents for CLL
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chlorambucil
CTX |
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2 nucleoside analogs for CLL
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cladribine
fludarabine |
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standard tx for CLL
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fludarabine
CTX rituximab |
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pts with p53 mutation receive ___ aka ___
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anti-CD52
alemtuzumab |
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only cure for CLL is ___
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allogeneic SC transplant
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in Richter's syndrome, CLL transforms to ___, e.g.
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aggressive lymphoma
DLBCL |
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T/F: CLL predisposes to second primary ca
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true
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