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25 Cards in this Set
- Front
- Back
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Which coagulation factors are tested by a PT?
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tests the extrinsic pathway so factors I, II, V, VII, & X
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Which coagulation factors are tested by a PTT?
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Tests the intrinsic pathway so all except VII and XIII
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What is tested in the BT?
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Platelet function
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What disorder results in an increased PTT and BT?
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von Willebrand's disease (functional deficiency of VIII)
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What are the characteristic findings in DIC?
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Prolonged PT, PTT and BT with increased Fibrin degredation products and schistocytes
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What is the defect in Factor V Leiden?
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Factor V has a mutation that prevents it from being cleaved by protein C
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What happens if you give Warfarin to someone with protein C or S deficiency?
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hemorrhagic skin necrosis
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What is the MOA of Warfarin?
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blocks vit K dependent factors: II, VII, IX, X protein C and protein S
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What is the MOA of Heparin?
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Activates antithrombin III which degrades IXa, Xa. XIa and XIIIa
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How do you treat Warfarin overdose?
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Fresh frozen plasma and IV vit K
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How do you treat Heparin overdose?
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protamine
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What is the major complication of Heparin use and how do you treat it?
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Heparin Induced Thrombocytopenia
treat by switching to argatroban, lepirudin or bivalirudin |
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What parameter is monitored in Heparin therapy?
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PTT
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What parameters are monitored in Warfarin therapy?
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PT/INR
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What is the deficiency in Hemophilia A? B?
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VIII; IX
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What is the MOA of tPA?
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activate conversion of plasminogen to plasmin in order to degrade fibrin clots and fibrinogen
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What is the MOA of agatroban?
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directly inhibits thrombin
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What is the MOA of aspirin?
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Irreversibly acetylates cyclooxygenase (COX-1 and COX-2) inhibiting conversion of arachidonic acid to thromboxane A2
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What is the MOA of Clopidogrel/ticlodipine?
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Inhibit platelet aggregation by irreversibly blocking ADP receptors and prevent GP IIb/IIIa expression
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What is the major side effect of ticlodipine?
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neutropenia, presents with fever and mouth ulcers
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What is MOA of Abciximab?
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monoclonal Ab that binds and blocks IIb/IIIa on activated platelets
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What is the defect in Bernard-Soulier disease?
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decreased GpIb leads to defect in platelet to collagen adhesion
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What is the defect in Glanzmann's thrombasthenia?
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decreased GpIIb/IIIa leads to defect in platelet to platelet aggregation
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What is the pathogenesis of ITP?
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Autoimmune destruction of peripheral platelets
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What is the pathogenesis of TTP?
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deficiency of ADAMTS 13 leads to decreased degredation of vWF multimers and these multimers promote platelet aggregation and thrombosis, microangiopathic RBC destruction
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