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27 Cards in this Set
- Front
- Back
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Processes of blood cell production and development of various cells of the blood |
Hematopoiesis |
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Hematopoiesis begins inthe yolk sac durin ____ of life |
1st few weeks |
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When does the spleen begin hematopoiesis |
3-6 months |
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hematopoiesis shifts from the liver to the _______ joins in medullary at 7 months |
bone marrow |
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When does the liver and spleen have ceased hematopoisis |
Birth |
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process that generates diverse cell populations |
Differentiation |
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has capability for continous self replication and also to differentiate into a mutipotential stem cell |
Hematopoietic Stem Cell |
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becomes commited to support prgenitor cells for myelopoiesis, erythropoiesis, monopoiesis, and megakaryopoiesis |
Multipotenital Progenitor |
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when 2 cells derived from the same precursor take a separate route of development |
Commitment |
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driven by growth factors and interleukins |
Proliferation |
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Precursor for the CFU |
Burst forming unit |
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commited to forming designated cells based on lineage |
Colong Forming Unit |
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entire process from commitment to when the cell has all the characteristics |
Maturation |
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All blood cells are derived from a single progenitor stem cell called |
Hematopoietic Stem Cell HSC |
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Mediate, proliferation, differentiation, and maturation |
Cytokines |
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B cells have what cytokines |
IL-1,2,4,5,6 |
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T cell have what cytokines |
IL-2,4 |
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PMN cytokines |
GM-CSF, G-CSF, IL-3 |
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Mono/Macro cytokines |
GM-CSF, M-CSF, IL-3 |
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Eos cytokines |
GM-CSF, IL-3,5 |
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Baso cytokines |
Baso-CSF, IL-3,5 |
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Erythrocyte cytokines |
GM-CSF, IL-3, EPO |
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Thrombocyte cytokines
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GM-CSF, IL-3, TPO |
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Source: Kidney, Liver Target: Erythoid progenitors Gene Location: 7q |
EPO |
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Source: Macrophages, endothelial cells, fibroblasts Target: stem cells, neutrophil precursors Gene Location: 17q |
G-CSF |
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Source: EPO Targe: Neutropil, eosinophil, monocyte, progenitors Gene Location: 5q |
GM-CSF |
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Source: endothelial cells, fibroblast, B cells, monos, macrophages, stromal cells Target: Mononuclear, phagocytes Gene Location: 5q |
M-CSF |
