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14 Cards in this Set
- Front
- Back
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What are some of the properties of BFU-E?
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cells in blood and marrow that mature into RBCs. Under the influence of BPA. Some self renewal capacity.
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What is CFU-E?
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cell that matures into RBC over 5 days.
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How does EPO increase erythropoiesis? (4)
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1. recruite additional cells into CFU-E pool
2. speed maturation of precursors 3. shift retics into blood 4. inhibit apoptosis of developing RBC precursors. |
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How is RBC survival measure in studies?
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radionuclide techniques
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How can RBC destruction be measured? (4)
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1. CO excretion
2. serum conc of indirect bili 3. fecal stercobilinogen or urine urobilinogen 4. serum LDH |
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What are three processes of normal erythrocyte aging?
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1. progressive decrease in enzyme quantity/activity
2. decrease in membrane factors 3. loss of cell volume |
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What are five processes for RBC destruction?
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1. fragmentation
2. osmotic lysis 3. cell rigidity 4. phagocytosis 5. complement cytolysis |
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How is disease and normal RBC destruction related?
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disease is an exaggeration of normal destruction mechanisms
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Normal cell destruction is normally intravascular or extravascular?
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extravascular
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In extravascular hemolysis where does the destruction take place? What pigments/enzymes are present?
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Phagocytosis by macrophages in spleen, liver and bone marrow. Increased indirect bilirubin, urinary urobilinogen, stool stercobilinogen, LDH.
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What levels are changed in intravascular hemolysis?
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-decreased haptoglobin and hemopexin (both form complexes which are cleared by the liver)
-increased methemalbumin -free Hb in plasma or urine -urine hemosiderin |
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Hereditary spherocytosis can be tested (so not MCHC) with what test?
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osmotic fragility
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Which three intrinsic hemolytic anemias have Heinz bodies?
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1. Thalassemia syndromes
2. unstable Hb 3. G6PD All these also have more intravascular than extravascular hemolysis |
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What is the complication of hemolysis associated with the gallbladder?
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Cholelithiasis- bilirubin gallstones.
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