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39 Cards in this Set
- Front
- Back
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4 myeloproliferative disorders
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PV
IMF CML ET |
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MPD most strongly associated with JAK2 mutation
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PV
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4 chromosomal abnormalities associated with MPD
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20q-
trisomy 8 trisomy 9 13q- |
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in IMF platelets are high/low
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yes
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3 examples of relative polycythemia
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dehydration
burns enteropathy |
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4 systemic causes of secondary polycythemia
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high altitude
CV disease pulmonary disease metHbemia |
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4 paraneoplastic causes of secondary polycythemia
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renal ca
uterine fibromyoma HCC cerebellar hemangioblastoma |
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to diagnose PV O2 saturation must be ___
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>92
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4 "A" criteria for PV
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raised cell mass
high O2 sat splenomegaly clonality marker, e.g. JAK2 mutation |
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4 "B" criteria for PV
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thrombocytosis
neutrophilia high neutrophil alkalkine phosphatase (NAP) high serum B12 |
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PV incidence peaks at ___ yo
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60
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PV pts are prone to bleeding/thrombosis
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yes
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PV pts are hyper/hypotensive
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hyper
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GI problem associated with PV
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PUD
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T/F: PV causes pruritus
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true
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___ occurs in 30% of PV
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MF
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___ occurs in 5-10% of PV
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acute leukemia
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if HCT in PV is >45, use ___ for tx
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phlebotomy
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2 drugs for cytotoxic myelosuppression
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hydroxyurea
busulphan |
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___ is valuable tx in pregnancy PV
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IFNa
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___ is used for platelet control. mechanism is ___.
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anagrelide
inhibition of budding |
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T/F: cytotoxic drugs prevent marrow fibrosis
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false: no drugs do
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platelets are >____/uL in ET
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600,000
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T/F: fibrosis is absent in ET
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false
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5 causes of secondary throbocythemia
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blood loss
chronic inflammation malignancy asplenia rebound |
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headache occurs in ___ (2)
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PV
ET |
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4 ET low-risk criteria
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age <60
no history of thrombosis platelets < 1,500,000/uL no smoking/obesity |
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2 ET high-risk criteria
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age > 60
Hx of thrombosis |
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3 platelet reducing drugs
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hydroxyurea
anagrelide IFNa |
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hydroxyurea can only be used if ___
anagrelide can only be used if ___. |
Plt < 600,000/uL
Plt < 400,000/uL |
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IMF is associated with ___megaly
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hepatospleno
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in IMF there may be ___ discomfort due to ___
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abdominal
massive splenomegaly |
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4 hypermetabolic symptoms in IMF
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weight loss
anorexia fever night sweats |
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transformation to ___ occurs in 10-30% of IMF pts
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AML
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early in IMF there is ___ (2)
late in IMF there is ___ (2) |
leukocytosis
thrombocytosis leukopenia thrombocytopenia |
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5 factors in IMF prognosis
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anemia
age catabolic symptoms leukocytosis/leukopenia cytogenetic abnormalities |
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6 tx for IMF
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transfusion/EPO
hydroxyurea splenectomy allopurinol thalidomide |
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___ may reverse fibrosis in IMF
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thalidomide
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in young IMF pts, ___ may by curative
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allogeneic SC transplant
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