Hematology 05: Hemolytic Anemia

Front 1

normal RBC lifespan is ___. at the end of it RBC is deleted by ___ in ___.

Back 1

90--120 days
MQs
reticuloendothelial system

Front 2

reticuloendothelial system includes ___ (2)

Back 2

spleen
liver

Front 3

in HA RBC lifespan shortens to ___

Back 3

<15 days

Front 4

Hburia implies ___ hemolysis

Back 4

intravascular

Front 5

Hb is ___toxic

Back 5

nephro

Front 6

intracorpuscular HAs are ___
extracorpuscular HAs are ___

Back 6

genetic
multifactorial/acquired

Front 7

in HA haptoglobin is increased/decreased

Back 7

decreased

Front 8

in HA LDH is increased/decreased

Back 8

increased

Front 9

BM finding in HA

Back 9

erythroid hyperplasia

Front 10

in erythroid hyperplasia the BM E/M ratio is ___

Back 10

1

Front 11

2 tests for peripheral hemolysis

Back 11

Coombs
osmotic fragility

Front 12

incidence of spherocytosis

Back 12

1:4500--1:1000

Front 13

spherocytosis is a ___ trait

Back 13

AD

Front 14

spherocytosis is caused by defect in ___ (3)

Back 14

ankyrin
spectrin
Band3

Front 15

spherocytosis presents with ___ (4)

Back 15

mild anemia
mild splenomegaly
jaundice
pigmented bile stones

Front 16

spherocytosis is ___cytic and ___chromic

Back 16

micro
hyper

Front 17

reticulocyte count in spherocytosis

Back 17

5--20

Front 18

tx for spherocytosis (3)

Back 18

splenectomy
cholecystectomy
folate supplement

Front 19

test for spherocytosis

Back 19

osmotic fragility

Front 20

2 enzyme deficiencies causing intracorpuscular HA

Back 20

pyruvate kinase
G6PD

Front 21

PK deficiency is a ___ trait

Back 21

AR

Front 22

PK deficiency presents with ___ (3)

Back 22

severe congenital anemia
severe jaundice
splenomegaly

Front 23

___ is a test for PK deficiency

Back 23

autohemolysis test

Front 24

G6PD deficiency is a ___ trait. it is more common in ___ areas.

Back 24

XLR
malarial

Front 25

G6PD makes G6P into ___.
in the process, ___ is converted to ___.

Back 25

6 phosphogluconate
NADP
NADPH

Front 26

normal isoform of G6PD is ___.

Back 26

B

Front 27

A+ type G6PD is present in ___. it is functionally ___.

Back 27

20% of african americans
normal

Front 28

A- type G6PD is present in ___. it is functionally ___

Back 28

11% of African population
deficient under stress

Front 29

Mediterranean type G6PD is present in ___ (2).

Back 29

mediterranean population
sephardic Jews

Front 30

PB finding in G6PD HA

Back 30

Heinz bodies

Front 31

2 kinds of autoimmune HA (AIHA)

Back 31

warm Ab
cold Ab

Front 32

warm AIHA is caused by ___ or ___ on RBCs

Back 32

IgG
C3

Front 33

3 scenarios for warm AIHA

Back 33

secondary to systemic immune disorder (SLE)
secondary to lymphoproliferative disease (NHL, CLL)
idiopathic

Front 34

warm AIHA presents with ___ (3)

Back 34

mild to severe hemolysis
splenomegaly
remissions/exacerbations

Front 35

cold AIHA is caused by

Back 35

IgM

Front 36

3 scenarios for cold AIHA

Back 36

infectious
secondary to lymphoproliferative disease
idiopathic

Front 37

2 infections which cause cold AIHA

Back 37

mycoplasma
IMN

Front 38

cold AIHA presents with ___ (2)

Back 38

acrocyanosis
mild hemolysis

Front 39

cold AIHA is more/less responsive to steroids, because ___.

Back 39

less
more complement-dependent