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20 Cards in this Set
- Front
- Back
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2 kinds of anemia
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hypo-regenerative
hyper-regenerative |
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in hypo-regenerative anemia there is ___.
in hyper-regenerative there is ___. |
deficient erythropoiesis
excess RBC destruction |
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ACD is NOT caused by ___ (3)
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marrow replacement by tumor
hemorrhage hemolysis |
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ACD has ___ferremia with ___ Fe stores
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hypo
normal |
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response to ___ is blunted in ACD
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EPO
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T/F: hemorrhage is a cause of cancer-related anemia
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true
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in ACD BM interstitium is infiltrated by excess ___
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Fe
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EPO is produced in ___ (2)
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kidney
liver |
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T/F: EPO is produced in brain
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true; trace amounts
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EPO prevents apoptosis of ___ progenitors. this are called ___ (3)
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late erythroid
BFU-E CFU-E erythroblasts |
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EPOR can be activated by ___ (4)
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EPO
EPO-mimetic bivalent Ab disulfide bond |
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EPOR is a ___
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homodimer
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hypoxia causes release of ___. this increases/decreases EPO.
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HIF-1
increases |
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inflammatory cytokines like ___ increase/decrease EPO
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IL-1
decrease |
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___ cells in kidney regulate EPO release
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peritubular interstitial
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tx for anemia of renal failure and ACD
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EPO
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T/F: recombinant EPO is not as good as endogenous
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false
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2 cancers which can have BM infiltration with only mild anemia
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prostate
breast |
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most common cause of anemia worldwide
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Fe deficiency
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ACD is ___cytic and ___chromic
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normo
normo |
