Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
75 Cards in this Set
- Front
- Back
|
PROERYTHROBLAST -> ? -> ?
|
proerythroblast -> reticulocyte -> erythrocyte
|
|
|
myeold stem cells
|
myeloblast
monoblast megakaryoblast |
|
|
myeloblast -> ? -> ? -> ? -> ? -> ???
|
myeloid stem cell -> myeloblast -> promyelocyte -> myelocyte -> metamyelocyte -> stab cell -> neutrophil, eosinophil, basophil
|
|
|
monoblast -> ?
|
monoblast -> monocyte
|
|
|
megakaryoblast -> ? -> ?
|
megakaryoblast -> megakaryocyte -> platelets
|
|
|
lymphoid stem cell -> ? -> ? -> ??
|
lymphoid stem cell -> b & t cell -> plasma cell & active t cell
|
|
|
wbc differential from highest to lowest
|
"neutrophils like making everything better":
neutrophils lyphocytes monocytes eosinophil basophil |
|
|
allows the rbc to transport co2 from periphery to lungs for elimination
|
physiologic chloride shift
|
|
|
mononuclear cells
|
lymphocytes and monocytes
|
|
|
basophilic stippling
|
"TAILS":
thalassemia anemia of chronic disease iron def. anemia lead poisoning |
|
|
basophilic granules of basophil contain these
|
hep - anticoagulant
histamine - VD leukotrienes |
|
|
can bind IgE to membranes in type I hypersensitivity reactions
|
mast cells
|
|
|
eosinophic granules produce these
|
histaminase
arylsulfatase |
|
|
causes of eosinophila
|
NAACP:
neoplasm asthma allergic processes collagen vascular disease parasites |
|
|
with azurophilic primary granules called lysosymes
|
neutrophils
|
|
|
rh+ blood transfusion into rh- individual
|
massive igG production
|
|
|
spiny appearance in abetalipoprotinemia of rbc
|
acanthocyte
|
|
|
rbc without membrane or central pallor in autoimmune hemolysis
|
spherocyte
|
|
|
schistocytes in
|
dic
traumatic hemolysis MAHA |
|
|
bm pushes rbc out too quickly in myelofibrosis
|
tear drop cell
|
|
|
HALT cells
|
target cells
|
|
|
nonuniform shapes in ttp/hus, dic, microvascular damage
|
poikilocytes
|
|
|
burr cells
|
ttp hus
|
|
|
nuclear remnant left in sickle cell
|
howell-jowell bodies
|
|
|
precipitated protein stuck on side of rbc with g6pd
|
heinz body
|
|
|
basophilic stippling
|
lead poisoning
porphyria post-splenectomy |
|
|
microcytic, hypochromic anemias
|
SILT:
sideroblastic anemia iron deficiency anemia lead poisoning thalassemia |
|
|
macrocytic anemias
|
(nuclear division defects)
megaloblastic anemia drugs blocking dna synthesis marked reticulocytosis myelodysplasia severe hypothyroidism |
|
|
normocytic, normochromic anemias
|
acute hemorrhage
enzyme defects rbc membrane defects? bone marroe disorders hemoglobinopathies autoimmune hemolytic anemia anemia of chronic cisease - early renal failure early hypothyroidism |
|
|
indicate rbc hemolysis in labs
|
low serum haptoglobine and high serum LDH
|
|
|
disinguish between immune/ vs non-immune mediated rbc hemolysis
|
coombs' test
|
|
|
anemia caused by destruction of multipotent myeloid stem cells
|
aplastic anemia
|
|
|
pathologic features include pancytopenia with normal cell morphology; hypocellular bone marrow with fatty infiltration
|
aplastic anemia
|
|
|
treatments of sickle cell disease
|
hydroxyurea - increase HbF
bone marrow transplantation |
|
|
b chain mutation where charged GLU replaced with charged LYS
|
HbC defect
|
|
|
cardiac fuilure to due secondary hemochromatosis
|
B-thalassemia - due to chronic transfusion therapy
|
|
|
anemia with sx's of hyperbilirubin and high reticulocyte count
|
hemolytic anemia
|
|
|
warm agglutinin
|
chronic anemia seen in SLE, CLL, or drugs (pac pads)
|
|
|
cold agglutinin
|
seen in recovery from Mycoplasma pneumoniae or infectious mononucleosis
|
|
|
defect where rbcs are small and rounch without central pallor
|
hereditary spherocytosis
|
|
|
intravascular hemolysis due to lytic activity of the complement
|
PNH
|
|
|
intravascular hemolysis seen in DIC, TTP/HUS, SLE, or malignant hypertension
|
microangiopathic anemia
|
|
|
activation of coagulation cascade leading to microthrombi and global consumption of platelets, fibrin, and coagulation factors
|
DIC
|
|
|
lab findings for dic
|
increased PT
increased PTT increased fibrin split products (d dimers) |
|
|
antiplatelet antibodies with increased megakaryocytes
|
itp
|
|
|
plately abnormality that causes neurologic and renal symptoms and increased LDH
|
TTP
|
|
|
anemia that involves platelet abnormalities
|
aplastic anemia
microangiopathic hemolytic anemia |
|
|
factor IX deficiency
|
hemophilia B
|
|
|
defect of platelet adhesion with decreased factor VIII survival
|
von wildebrand's disease
|
|
|
defective platelet adhesion (decreased GP Ib)
|
bernard-soulier disease
|
|
|
defect of platelet aggregation (decrease GP IIb-IIIa)
|
glanzmann's thrombasthenia
|
|
|
increase BT
|
qualitative platelet defects
|
|
|
low platelet count + increased BT
|
thrombocytopenia
|
|
|
increased PTT
|
hemophilia A and B
|
|
|
increased BT and PTT
|
von Wildebrand's disease
|
|
|
low platelet count, increased BT, increased PT and increased PTT
|
DIC
|
|
|
origin of RS cells
|
CD30+ and CD15+ b cell origin
|
|
|
good prognosis with hodgkin's lymphoma
|
many lymphocytes and less RS cells
|
|
|
lacunar cells
|
nodular sclerosis
|
|
|
excellent prognosis hodgkin's lymphoma
|
lymphocyte predominant
|
|
|
M spike
|
multiple myeloma - IgG/A
waldenstrom's macroglobulinemia - IgM |
|
|
appears like CLL with focal mass and low grade
|
small lymphocytic lymphoma
|
|
|
most common non-hodgkin's lymphoma
|
follicular (small cleaved)
|
|
|
t(14,18)
|
follicular lymphoma
|
|
|
bcl-2 expression
|
follicular lymphoma
|
|
|
poor prognosis CD5+ in adults
|
mantle cell lymphoma
|
|
|
t(11,14)
|
mantle cell lymphoma
|
|
|
most common non-hodgkin's lymphoma of children
|
lymphoblastic lymphoma
|
|
|
"starry sky" appearance in kids
|
burkit's lymphoma
|
|
|
t(8,14)
|
burkitt's
|
|
|
c-myc
|
burkitt's
|
|
|
bcr-abl hybrid
|
CML
|
|
|
t(15,17)
|
AML - m3 type
|
|
|
t(11,22)
|
ewing's sarcoma
|
|
|
t(11,14)
|
mantle cell lymphoma
|
