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75 Cards in this Set

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PROERYTHROBLAST -> ? -> ?
proerythroblast -> reticulocyte -> erythrocyte
myeold stem cells
myeloblast
monoblast
megakaryoblast
myeloblast -> ? -> ? -> ? -> ? -> ???
myeloid stem cell -> myeloblast -> promyelocyte -> myelocyte -> metamyelocyte -> stab cell -> neutrophil, eosinophil, basophil
monoblast -> ?
monoblast -> monocyte
megakaryoblast -> ? -> ?
megakaryoblast -> megakaryocyte -> platelets
lymphoid stem cell -> ? -> ? -> ??
lymphoid stem cell -> b & t cell -> plasma cell & active t cell
wbc differential from highest to lowest
"neutrophils like making everything better":
neutrophils
lyphocytes
monocytes
eosinophil
basophil
allows the rbc to transport co2 from periphery to lungs for elimination
physiologic chloride shift
mononuclear cells
lymphocytes and monocytes
basophilic stippling
"TAILS":
thalassemia
anemia of chronic disease
iron def. anemia
lead poisoning
basophilic granules of basophil contain these
hep - anticoagulant
histamine - VD
leukotrienes
can bind IgE to membranes in type I hypersensitivity reactions
mast cells
eosinophic granules produce these
histaminase
arylsulfatase
causes of eosinophila
NAACP:
neoplasm
asthma
allergic processes
collagen vascular disease
parasites
with azurophilic primary granules called lysosymes
neutrophils
rh+ blood transfusion into rh- individual
massive igG production
spiny appearance in abetalipoprotinemia of rbc
acanthocyte
rbc without membrane or central pallor in autoimmune hemolysis
spherocyte
schistocytes in
dic
traumatic hemolysis
MAHA
bm pushes rbc out too quickly in myelofibrosis
tear drop cell
HALT cells
target cells
nonuniform shapes in ttp/hus, dic, microvascular damage
poikilocytes
burr cells
ttp hus
nuclear remnant left in sickle cell
howell-jowell bodies
precipitated protein stuck on side of rbc with g6pd
heinz body
basophilic stippling
lead poisoning
porphyria
post-splenectomy
microcytic, hypochromic anemias
SILT:
sideroblastic anemia
iron deficiency anemia
lead poisoning
thalassemia
macrocytic anemias
(nuclear division defects)
megaloblastic anemia
drugs blocking dna synthesis
marked reticulocytosis
myelodysplasia
severe hypothyroidism
normocytic, normochromic anemias
acute hemorrhage
enzyme defects
rbc membrane defects?
bone marroe disorders
hemoglobinopathies
autoimmune hemolytic anemia
anemia of chronic cisease - early renal failure
early hypothyroidism
indicate rbc hemolysis in labs
low serum haptoglobine and high serum LDH
disinguish between immune/ vs non-immune mediated rbc hemolysis
coombs' test
anemia caused by destruction of multipotent myeloid stem cells
aplastic anemia
pathologic features include pancytopenia with normal cell morphology; hypocellular bone marrow with fatty infiltration
aplastic anemia
treatments of sickle cell disease
hydroxyurea - increase HbF
bone marrow transplantation
b chain mutation where charged GLU replaced with charged LYS
HbC defect
cardiac fuilure to due secondary hemochromatosis
B-thalassemia - due to chronic transfusion therapy
anemia with sx's of hyperbilirubin and high reticulocyte count
hemolytic anemia
warm agglutinin
chronic anemia seen in SLE, CLL, or drugs (pac pads)
cold agglutinin
seen in recovery from Mycoplasma pneumoniae or infectious mononucleosis
defect where rbcs are small and rounch without central pallor
hereditary spherocytosis
intravascular hemolysis due to lytic activity of the complement
PNH
intravascular hemolysis seen in DIC, TTP/HUS, SLE, or malignant hypertension
microangiopathic anemia
activation of coagulation cascade leading to microthrombi and global consumption of platelets, fibrin, and coagulation factors
DIC
lab findings for dic
increased PT
increased PTT
increased fibrin split products (d dimers)
antiplatelet antibodies with increased megakaryocytes
itp
plately abnormality that causes neurologic and renal symptoms and increased LDH
TTP
anemia that involves platelet abnormalities
aplastic anemia
microangiopathic hemolytic anemia
factor IX deficiency
hemophilia B
defect of platelet adhesion with decreased factor VIII survival
von wildebrand's disease
defective platelet adhesion (decreased GP Ib)
bernard-soulier disease
defect of platelet aggregation (decrease GP IIb-IIIa)
glanzmann's thrombasthenia
increase BT
qualitative platelet defects
low platelet count + increased BT
thrombocytopenia
increased PTT
hemophilia A and B
increased BT and PTT
von Wildebrand's disease
low platelet count, increased BT, increased PT and increased PTT
DIC
origin of RS cells
CD30+ and CD15+ b cell origin
good prognosis with hodgkin's lymphoma
many lymphocytes and less RS cells
lacunar cells
nodular sclerosis
excellent prognosis hodgkin's lymphoma
lymphocyte predominant
M spike
multiple myeloma - IgG/A

waldenstrom's macroglobulinemia - IgM
appears like CLL with focal mass and low grade
small lymphocytic lymphoma
most common non-hodgkin's lymphoma
follicular (small cleaved)
t(14,18)
follicular lymphoma
bcl-2 expression
follicular lymphoma
poor prognosis CD5+ in adults
mantle cell lymphoma
t(11,14)
mantle cell lymphoma
most common non-hodgkin's lymphoma of children
lymphoblastic lymphoma
"starry sky" appearance in kids
burkit's lymphoma
t(8,14)
burkitt's
c-myc
burkitt's
bcr-abl hybrid
CML
t(15,17)
AML - m3 type
t(11,22)
ewing's sarcoma
t(11,14)
mantle cell lymphoma