Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
54 Cards in this Set
- Front
- Back
|
triggers primary hemostasis upon exposure to subendothelial collagen |
platelets |
|
|
MPV of platelet |
8 to 10 fL |
|
|
platelets arise from unique bone marrow cells called |
megakaryocytes |
|
|
polyploid, possessing multiple chromosome copies |
megakaryocytes |
|
|
act in opposition to balance megakaryocytopoiesis (2) |
GATA-1 & MYB |
|
|
are diploid and participate in normal mitosis (2) |
BFU-Meg & CFU-Meg |
|
|
a form of mitosis that lacks telophase and cytokinesis |
endomitosis |
|
|
a single megakaryocyte sheds how many platelets |
2000 to 4000 platelets |
|
|
platelet shedding |
thrombopoiesis/ thrombocytopoiesis |
|
|
least differentiated megakaryocyte precursor |
MK-1 Stage or Megakaryoblast |
|
|
a series of membrane-lined channels that invade from the plasma membrane and grow inward to subdivide the entire cytoplasm |
Demarcation System |
|
|
nuclear lobularity first becomes apparent as an indentation at the 4N replication stage |
MK-II stage or Promegakaryocyte |
|
|
a nucleic acid dye in megakaryocyte flow cytometry |
mepacrine |
|
|
meaning of FISH |
Fluorescent in Situ Hybridization |
|
|
disappears as differentiation proceeds |
CD34 Marker |
|
|
a marker located on the IIb portion |
glycoprotein IIb/IIIa (CD41) |
|
|
growth factor TPO volume |
70,000 Dalton moleculde |
|
|
normal peripheral blood platelet count |
150 to 400 x 10^9/L |
|
|
peripheral blood platelet count at 65 yrs old in men |
122 to 350 x 10^9/L |
|
|
peripheral blood platelet count at 65 yrs old in women |
140 to 379 x 10^9/L |
|
|
immediately available in times of demand |
sequestered platelets |
|
|
other term for reticulated platelets |
stressed platelets |
|
|
appear in compensation for thrombocytopenia; carry free ribosomes |
stressed platelets |
|
|
(2) predominate in the plasma layer |
neutral phospholipids phosphatidylcholine & sphingomyelin |
|
|
a unsaturated fatty acid that becomes converted to the eicosanoids prostaglandin |
arachidonic acid |
|
|
flips to the outer surface upon activation |
phosphatidylserine |
|
|
moves freely throughout the hydrophobic intrnal layer |
eterified cholesterol |
|
|
platelet membrane surface |
glycocalyx |
|
|
glycosylated receptors that respond to cellular and humoral stimuli |
ligands or agonists |
|
|
SCCS |
surface-connected canalicular system |
|
|
twists spongelike throughout the platelet |
SCCS |
|
|
a condensed remnant of the rough endoplasmic reticulum |
dense tubular system |
|
|
"control center" for platelet activation |
dense tubular system |
|
|
CAM |
cell adhesion molecule |
|
|
STR |
seven-transmembrane receptor |
|
|
heterodimeric CAMs that integrate their ligands |
Integrins |
|
|
promote platelet adhesion |
laminin and fibronectin |
|
|
a key collagen receptor that also binds the adhesive protein thrombospondin |
GP IV |
|
|
the basis for the most common inherited bleeding disorder |
Von Willebrand Disease |
|
|
a severe mucocutaneous bleeding disorder |
Glanzmann thrombasthenia |
|
|
TRAP |
thrombin receptor activation peptide |
|
|
a thick circumferential bundle of microtubules maintains the platelet's discoid shape |
platelet cytoskeleton |
|
|
contractile in platelets an anchors the plasma membrane glycoproteins and proteoglycans. |
Actin |
|
|
medium gray in osmium dye transmission electron microscopy |
a-granules |
|
|
these granules appear later than a-granules in megakaryocyte differentiation and stain black when treated with osmium |
dense bodies |
|
|
digests unused VWF |
VWF-cleaving protease |
|
|
a key part of primary hemostasis which in arteries may end with the formation of a "white clot" |
platelet aggregation |
|
|
a clot composed primarily of platelets and VWF |
white clot |
|
|
dense granule contents triggers secondary hemostasis |
coagulation |
|
|
essential to wound repair |
red clot |
|
|
the polar phospholipid on which twi coagulation pathway complexes assemble |
phosphatidylserine |
|
|
control cellular activation for all cells at the inner membrane surface |
G proteins |
|
|
one of the two essential platelet activation pathways triggered by the G proteins |
eicosanoid synthesis pathway |
|
|
half life of TXA2 |
30 seconds |
