Hema 2 Wbc Abnormalities

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PELGER-HUET ASSOCIATED CONDITION

(Code: PPCM!!)

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Pelger-Huet

Psedopelger-Huet

Chronic Myelogenous Leukemia

Myelodysplastic SyndromeHy

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Hypersegmentation associated condition

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Megaloblastic Leukemia

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Alder-Reilly Inclusion Associated Condition

(CODE: AMH)

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Alder-Reilly Anomaly

Mucopolysaccharidoses

Hunter’s Syndrome

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Chediak-Higashi Syndrome associated condition

(Code: CRA)

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Chediak-Higashi

Recurrent infections

Albinism

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● Genetic condition characterized by Dohle body – like inclusions in neutrophils, eosinophils and monocyte

● Abnormally large and poorly granulated platelets and thrombocytopenia frequently co-exist in this condition

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May - Heglin Anomaly

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● Morphology: Giant red, blue to grayish round inclusions in cytoplasm

● Defect or Change: large cytoplasmic inclusions that are deficient in enzymes for phagocytosis

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Chediak – Higashi Syndrome

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● Gigantic peroxidase – positive deposits represent abnormal lysosomal development in neutrophils and other leukocyte (monocyte and lymphocyte)

● Neutrophils displays impaired chemotaxis and delayed killing of ingested bacteria

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Chediak – Higashi Syndrome

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Autosomal recessive

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Alder-Reilly Inclusion

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These purple-red/black particles are precipitated mucopolysaccharides seen primarily in neutrophils, eosinophils, and basophils

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Alder-Reilly Inclusion

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Alder-Reilly is commonly seen in patients with _______, _______, and _________ types of genetic mucopolysaccharidosis

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Hurler

Hunter

Maroteaux-Lamy

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Large purple – red/black coarse cytoplasmic granules

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Alder-Reilly Inclusion

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Inclusions can resemble very coarse toxic granulation

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Alder-Reilly Inclusion

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Genetically acquired autosomal dominant disorder

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Pelger-Huet Anomaly

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Hypersegmentation is Associated with deficiencies of ______ or ______

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Vit B12 or folic acid

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Alder reilly morphology

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Large purple – red/black coarse cytoplasmic granules

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Chediak higashi morphology

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Giant red, blue to grayish round inclusions in cytoplasm

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Can be seen as single or multiple light blue staining inclusions on Wright-stained blood smears

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Dohle bodies

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Dohle Bodies associated condition

(STB)

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Severe infections

toxic states

burns

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Represent aggregates of rough endoplasmic reticulum

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Dohle Bodies

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are azurophilic (primary) granules that are peroxidase positive

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Toxic granulation

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Large purple to black azurophilic granules

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Toxic granulation

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Toxic Granulation associated condition

(CODE: ITBMC!)

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infections

toxic states

burns

malignancy

chemical poisoning

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- Pink to red rod-shaped cytoplasmic structures

- peroxidase +

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Auer Rods

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Auer Rods is seen in

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Acute Myeloid Leukemia (AML),

Acute Myelomonocytic Leukemia (AMML)

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● Neutrophils with large homogenous round inclusions with nucleus wrapped around

Seen in Lupus Erythematosus

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LE CELLS

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LE CELL 3 Factors Need to Produce the Cell

(Code: ACP!)

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○ Antinuclear antibodies

○ Cell nuclei

○ Phagocytes with ingested material

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● Cells are similar to normal lymphocytes except that nucleus is notched, lobulated and cloverleaf-like

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REIDER CELLs

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Reider cells occurs in

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Chronic Lymphocytic Leukemia (CLL)

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Represent the bare nuclei of lymphocytes and neutrophils

Seen in increased proportions in lymphocytes particularly CLL

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Smudge Cell

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- Lymphocytes with hair like cytoplasmic projections surrounding the nucleus

- Thought to be B cell in origin

- Associated with Hairy Cell Leukemia

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Hairy Cell

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Hairy Cell stains positive with

(Code: TRAP)

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Tartrate Resistant Acid Phosphatase (TRAP)

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- Round lymphocyte cell with nucleus that is grooved and convoluted

- Represents leukemic phase of Mycosis fungoises (fungi)

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Sezary Cell

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Sezary cell is seen in

(CTCL)

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Cutaneous T – cell Lymphoma

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Cytoplasm stains a bright-red color and contains increased quantities of glycogen or intracellular deposits of amorphous matter

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Flame Cell

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Flame cell is associated with

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Increased immunoglobulins

Multiple Myeloma

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● Cytoplasm is completely field with Russell Bodies

● Plasma cell that contains small colorless vacuoles

● Seen in Multiple Myeloma

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Grape or Mott Cell