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19 Cards in this Set
- Front
- Back
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-plasma based -coagulation happens outside the body -coagulation studies |
in vitro |
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-cell based -coagulation happens INSIDE the body |
in vivo |
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same function as in vitro - formation of fibrin clot (irreversible) |
in vivo |
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in vivo coagulation pathway |
cell based coagulation |
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3 stages of cell based coagulation |
-initiation -amplification -propagation |
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-extrinsic tenase complex / pathway (starts with TF with F7) -generation of small amounts of factor Xa, factor IXa and thrombin |
initiation stage |
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fibroblasts and subendothelial cells (tissue bearing cells) that carry TF |
initiation stage |
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activates platelets and amplify coagulant activity on the platelet surface |
"priming" amounts of thrombin |
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is a cell important for maintaining primary and secondary hemostasis |
platelets |
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a critical co factor in the prothrombinase complex subsequently assembles on the activated platelet membrane |
activated factor V (FVa) |
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-critical component of the TENASE complex, which also assembles on the platelet surface |
factor 8a |
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sets the stage for the formation of the TENASE and PROTHROMBINASE complex |
platelet activation |
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the assembled enzyme complexes on the platelet surface rapidly lead to the production of enough FIIa to support additional platelet activation |
propagation |
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additional platelet activation leads to ever increasing amount of FIIa and subsequent fibrin formation |
propagation |
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phase where there is a great production of thrombin |
propagation |
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fibrin clot formation |
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has additional roles in stabilizing the hemostatic plug |
thrombin that is produced AFTER the clot forms |
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the platelet produced thrombin has multiple actions in addition to clotting fibrinogen. it also stabilizes the clot by: |
-activating FXIII -activating TAFI -cleaving the platelet PAR-4 receptor -being incorporated into the structure of the clot |
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TAFI means |
Thrombin activatable fibrinolysis inhibitor |
