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39 Cards in this Set
- Front
- Back
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Pathologic pattern for normal lymph node
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type of cell stimulated
not specific to exact cause normal nodal architecture (key) |
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proliferation of B lymphocytes in lymph nodes
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follicular hyperplasia
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Normal lymph nodes contents of lymphocytes
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mixture of B-cells and T-cells
T-cells express CD4 or CD8 B-cells have equivalent kappa and lambda light chains |
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Where is T cell proliferation?
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Paracortical hyperplasia
(like in mononucleosis) |
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What is occurring with sinus histiocytes?
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proliferation of macrophages
stim of antigen-presenting cells Ex: lymph nodes draining a carcinoma |
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3 most common causes of benign reactice lymphadenopathies
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follicular
paracortical sinus histiocytosis |
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4 non-Hodgkins lymphoma risk factors
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infections
medical conditions (AI disease) toxic chemicals age most have no known risk factors |
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WHO looks at what for lymphomas?
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B-cell v. T-cell;
mature v. immature |
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Working Formulation breakdown
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low grade
intermediate grade high grade |
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What happens to growth pattern in lymph nodes in lymphoma?
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loss of architecture (absence of GC and sinuses)
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Follicular v. diffuse
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Follicular still has GCs visible
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SLL v. CLL
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where the disease takes up shop
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What does CLL express?
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CD19, CD20, CD22, CD23 (not as frequent), co-express CD5
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Cytogenetics for prognosis of SLL
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13q14 good
trisomy 12 bad |
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Which is SLL/CLL have more light chains of?
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kappa
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What do smudge cells appear in?
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SLL/CLL
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Cytogenetics of follicular lymphoma
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t(14;18), Bcl2 proto-oncogene
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Small cleaved lymphocytes appear how?
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irregular shaped
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median survival of follicular lymphoma
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10 years (incurable w/ conventional chemo)
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What can follicular lymphoma progress to?
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large cell lymphoma
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Diffuse large b-cell lymphoma occurs in what populations?
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children and adults
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Diffuse large b-cell should be associated with what co-presentation?
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immune dysfunction (HIV, SCID, BM & organ transplants)
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molecular changes of diffuse large b-cell lymphoma
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Bcl-6
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What can be seen in diffuse large b-cell lymphoma histology?
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small lymphocytes
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Lymphoblastic lymphoma are diseases of what?
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children (w/ mediastinal mass)
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Lymphoblastic lymphoma has what immunophenotype?
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immature T-cell expressing CD3, co-expressing CD4&8
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Histology of lymphoblastic lymphoma
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mitotic figures
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Burkitt Lymphoma 2 types
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endemic (Africa, EBV+)
non-endemic (world-wide, 15-20% EBV+) |
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cytogenetics of Burkitt lymphoma
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t(8;14), c-myc
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When Burkitt lymphoma presents with bone marrow involvement, what is it considered?
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ALL
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Starry sky appearance typical or what? Made of what?
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Burkitt lymphoma; macrophages
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What has cytoplasmic-filled vacuoles?
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Burkitt Lymphoma (involved bone marrow)
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Distinctive cell of Hodgkin lymphoma
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Reed-Sternberg cell (an activated B-cell)
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Peak incidence of Hodgkin lymphoma?
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20s, smaller peak >50yo
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Spread of Hodgkin lymphoma?
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spreads along contiguous lymph nodes
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What does the Reed Sternberg cell do to form the tumor?
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secretes cytokines, recruits other cells
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What is not helpful for dx of Hodgkin Lymphoma?
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flow cytometry and cytogenetics
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What is associated with prognosis of Hodgkin Lymphoma?
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morphologic subtypes
-nodular sclerosis is good -lymphocyte predominance is very good -lymphocyte depletion is worst |
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What is stained in Hodgkin lymphoma? Which stain?
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CD30 immunohistochemical stain
-neoplastic stains for CD15/CD30, negative for CD45 (common leukocyte antigen) |
