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21 Cards in this Set

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defintition of pericarditis

Inflammation, infection or infiltration of pericardial sac, with or without pleural effusion

Name 2 dangerous complications of pericarditis


  • cardiac tamponade (if acute)

  • biventricular heart failure due to constrictive pericarditis (if chronic)

what are the symptoms of pericarditis?


  • Chest pain which is sudden, pleuritis and sharp
  • Chest pain relieved by sitting up and leaning forwards
  • Dyspnea and cough
  • Fever
  • Nausea and anorexia

Signs of pericarditis?


  • tachypnea and tachycardia
  • pericardial friction rub at LLSE

What is the triad of signs for cardiac tamponade?

Beck's triad (uncommon)


1. Muffled heart sounds


2. Distended neck veins


3. Hypotension

what are the 3 most relevant lab tests for pericarditis?

1. FBC --> look for high WBC


2. ESR and CRP are raised


3. Cardiac enzyme level raised

What ECG findings are there in pericarditis?

1. Diffuse ST elevation


2. followed by normalization and T-wave inversions later on

Describe the general management of pericarditis

1. stabilize ABCs and resuscitation


2. Relevant investigations


3. Refer to cardio for U/S, urgent referral if tamponade suspected


4. U/S guided pericardiocentesis if hemodynamically unstable


5. Drug therapy


6. Specific treatment to target the cause

What are the drug therapies for pericarditis?

1.NSAIDs: Ibuprofen 400-800mg PO q6-8h OR Aspirin 800mg q6-8h


2. Colchicine: 0.5-1mg/day in addition to NSAIDs


3. Steroids: Prednisolone 1mg/kg/day only if refractory to NSAIDs and colchicine or other reasons

Colchicine helps by preventing recurrence of viral and idiopathic pericarditis

When to start a patient with pericarditis on prednisolone?

1. refractory to NSAIDs and colchicine


2. Uremic pericarditis


3. immune-mediated pericarditis


4. connective tissue disease

what are the causes of pericarditis?

1. Infective


2. Neoplastic infiltration (Lung, Breast, Lymphoma, Leukemia)


3. Systemic diseases (Pancreatitis, Uremia, Autoimmune, CTD disorders)


4. Post-irradiation

Others: Dressler's syndrome

what is Dressler's syndrome?

Dressler's syndrome is a type of pericarditis, due to an immune system response after damage to heart tissue or to the pericardium, usually after AMI

definition of Myocarditis ?

inflammation of the heart, characterized by myocyte necrosis, cardiac dysfunction, heart failure

What are the 3 relevant lab investigations?

1. FBC --> WBC raised in 25%


2. ESR raised in 60%


3. Cardiac enzymes elevated in minority of patients

Symptoms of myocarditis?

1. Half of the patients will report a preceding viral illness


2. Other non-specific symptoms including: chest pain, dyspnea, palpitations, malaise and fatigue, fever

Signs of myocarditis?

1. Tachycardia disproportionate to fever


2. Cyanosis


3. Pericardial rub (Maybe)


4. Fever and tachypnea

Complications of myocarditis?

1. Heart failure


2. Cardiogenic shock and sudden cardiac death if very acute and progressive

ECG findings for myocarditis?

Sinus tachycardia most common




non specific ST and T wave changes, heart blocks, dysrhythmias

General management for myocarditis?

1. ABC and resuscitate


2. Investigations


3. Manage patient as per acute heart failure


4. treat dysrhythmia/heart blocks if present


5. Urgent echo (Cardio referral)


6. Drug therapy

What drugs are used for myocarditis?

1. ACE-I: Captopril 6.25-50 mg PO, TDS


2. Digoxin: 0.125-0.375 mg PO, once daily


3. Frusemide: 20-80 mg PO/IV BD/TDS, titrate


4. IVIG 2g/kg if viral aetiology


5. Immuno-suppressive therapy?

mainly to provide stable rhythm+diuresis and reduce effort of the heart/myocytes

what drugs are contraindicated in myocarditis? why?

NSAIDs, sympathomimetics and beta-blockers will increase myocardial necrosis